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Tamsulosin Hydrochloride
(CAS RN:106463-17-6 Product Number:T2749)

Structure

Tamsulosin Hydrochloride
Synonym 5-[(R)-2-[2-(2-Ethoxyphenoxy)ethylamino]propyl]]-2-methoxybenzenesulfonamide Hydrochloride

General Information

Product Number T2749

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Purity/Analysis Method >98.0%(HPLC)(T)
Storage Temperature
M.F. / M.W. C20H28N2O5S·HCl=444.97
CAS RN 106463-17-6
Related CAS RN 106133-20-4
MDL Number MFCD00922997
  • Product Details
  • Safety & Regulations
  • Reference & Application

Specification

Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 98.0 %
Specific rotation [a]20/D -17.5 to -20.5 deg(C=1, H2O)

Data of Reference

mp 230°C(dec.)(lit.)

References

Reaxys-RN 6896058
PubChem SID 125307965
Merck Index(14) 9049
RTECS# DB2430000

GHS

Pictogram
Signal Word Warning
Hazard Statements
  • H302
  • :Harmful if swallowed.
  • H315
  • :Causes skin irritation.
  • H319
  • :Causes serious eye irritation.
Precautionary Statements
  • P264
  • :Wash hands and face thoroughly after handling.
  • P270
  • :Do not eat, drink or smoke when using this product.
  • P280
  • :Wear protective gloves, eye protection.
  • P301+P312+P330
  • :If swallowed: Call a poison center or doctor if you feel unwell. Rinse mouth.
  • P302+P352+P332+P313+P362+P364
  • :If on skin: Wash with plenty of soap and water. If skin irritation occurs: Get medical advice or attention. Take off contaminated clothing and wash it before reuse.
  • P305+P351+P338+P337+P313
  • :If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice or attention.
  • P501
  • :Dispose of contents and container in accordance with local, regional, national regulations (e.g. US: 40 CFR Part 261, EU:91/156/EEC, JP: Waste Disposal and Cleaning Act, etc.).

Transport Information

HS Number 2935.90.9500

Application

Pharmacology study

References

  • Evaluation of the pharmacological selectivity profile of alpha1 adrenoceptor antagonists at prostatic alpha1 adrenoceptors: binding, functional and in vivo studies
    • B. A. Kenny, A. M. Miller, I. J. R. Williamson, J. O'Connell, D. H. Chalmers, A. M. Naylor, Br. J. Pharmacol. 1996, 118, 871.
  • Pharmacokinetics and plasma protein binding of tamsulosin hydrochloride in rats, dogs, and humans
    • H. Matsushima, H. Kamimura, Y. Soeishi, T. Watanabe, S. Higuchi, M. Tsunoo, Drug Metab. Dispos. 1998, 26, 240.
  • Comparison of two alpha1-adrenoceptor antagonists, naftopidil and tamsulosin hydrochloride, in the treatment of lower urinary tract symptoms with benign prostatic hyperplasia: a randomized crossover study

PubMed Literature

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