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BAY 11-7082
(CAS RN:19542-67-7 Product Number:T2846)


BAY 11-7082
Synonym (E)-3-(p-Toluenesulfonyl)acrylonitrile
Synonym (E)-3-Tosylacrylonitrile

General Information

Product Number T2846

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Purity/Analysis Method >98.0%(HPLC)(N)
Storage Temperature 0-10°C
M.F. / M.W. C10H9NO2S=207.25
CAS RN 19542-67-7
Related CAS RN
MDL Number MFCD00712162
  • Product Details
  • Safety & Regulations
  • Reference & Application


Purity(HPLC) min. 98.0 area%
Purity(with Total Nitrogen) min. 98.0 %
Melting point 132.0 to 136.0 deg-C


Reaxys-RN 2049371
PubChem SID 135727354
RTECS# UD1430000


Signal Word Warning
Hazard Statements
  • H302
  • :Harmful if swallowed.
  • H315
  • :Causes skin irritation.
  • H319
  • :Causes serious eye irritation.
Precautionary Statements
  • P264
  • :Wash hands and face thoroughly after handling.
  • P270
  • :Do not eat, drink or smoke when using this product.
  • P280
  • :Wear protective gloves, eye protection.
  • P301+P312+P330
  • :If swallowed: Call a poison center or doctor if you feel unwell. Rinse mouth.
  • P302+P352+P332+P313+P362+P364
  • :If on skin: Wash with plenty of soap and water. If skin irritation occurs: Get medical advice or attention. Take off contaminated clothing and wash it before reuse.
  • P305+P351+P338+P337+P313
  • :If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice or attention.
  • P501
  • :Dispose of contents and container in accordance with local, regional, national regulations (e.g. US: 40 CFR Part 261, EU:91/156/EEC, JP: Waste Disposal and Cleaning Act, etc.).

Transport Information

HS Number 2930.90.2900


Bay 11-7082: An Inhibitor of NFκB and IκBα Phosphorylation

Bay 11-7082 and Bay 11-7085 [B4845] are inhibitors of nuclear factor-κB (NFκB) and phosphorylation of IκBα. They have been shown to inhibit cell proliferation and induce apoptosis of a variety of cells. NFκB is a protein complex controls transcription of DNA and inflammatory cytokine production. Researches demonstrate that inhibition of NFκB can suppress the angiogenic potential and metastasis of cancer cells. IκBα is one member of a family of cellular proteins that function to inhibit the NF-κB transcription factor. In addition, they have anti-inflammatory activity.


PubMed Literature

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