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(CAS RN:220620-09-7 Product Number:T3589)


Synonym 9-tert-Butylglycylamidominocycline

General Information

Product Number T3589

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Purity/Analysis Method >98.0%(HPLC)
Storage Temperature <0°C
M.F. / M.W. C29H39N5O8=585.66
CAS RN 220620-09-7
Related CAS RN
MDL Number MFCD00935753
  • Product Details
  • Safety & Regulations
  • Reference & Application


Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 97.0 %
Specific rotation [a]20/D -189 to -208 deg(C=0.15, methanol)
Specific rotation(value) -208 to -189 deg


Reaxys-RN 8379453
PubChem SID 354335260
Merck Index(14) 9432
RTECS# QI7619500


Signal Word Danger
Hazard Statements
  • H318
  • :Causes serious eye damage.
  • H360
  • :May damage fertility or the unborn child.
  • H410
  • :Very toxic to aquatic life with long lasting effects.
Precautionary Statements
  • P201
  • :Obtain special instructions before use.
  • P202
  • :Do not handle until all safety precautions have been read and understood.
  • P273
  • :Avoid release to the environment.
  • P280
  • :Wear protective gloves, protective clothing, face protection.
  • P305+P351+P338+P310
  • :If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a poison center or doctor.
  • P308+P313
  • :If exposed or concerned: Get medical advice or attention.
  • P391
  • :Collect spillage.
  • P405
  • :Store locked up.
  • P501
  • :Dispose of contents and container in accordance with local, regional, national regulations (e.g. US: 40 CFR Part 261, EU:91/156/EEC, JP: Waste Disposal and Cleaning Act, etc.).

Transport Information

UN Number 3077
Class 9
Packing Group III
HS Number 2941.30.0000


Tigecycline: The First Glycylcycline Antimicrobial Agent with Activity against Multidrug-Resistant Strains

Tigecycline (GAR-936) is the first glycylcycline antimicrobial agent with expanded broad-spectrum activity against both Gram-negative (except for Pseudomonas aeruginosa) and Gram-positive aerobes and anaerobes. Furthermore, the spectrum of activity extends to multidrug-resistant strains of Staphylococcus aureus (MRSA), Streptococcus pneumoniae, vancomycin-resistant enterococci (VRE), and Enterobacteriaceae, including extended-spectrum β-lactamase (ESBL) producing strains. In addition, tigecycline is able to overcome the major resistance mechanisms, ribosomal protection and efflux. Tigecycline inhibits protein translation in bacteria by binding to the 30S ribosomal subunit and blocking entry of aminoacyl-tRNA molecules into the A site of the ribosome. Tigecycline binds to bacterial ribosomes in a novel way that allows it to overcome tetracycline resistance due to ribosomal protection. (The product is for research purpose only.)


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