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Sultamicillin Tosylate Dihydrate
(CAS RN:83105-70-8 Product Number:U0097)


Sultamicillin Tosylate
Synonym Sultamicillin Tosilate Dihydrate

General Information

Product Number U0097

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Purity/Analysis Method >98.0%(GC)(T)
Storage Temperature 0-10°C
M.F. / M.W. C25H30N4O9S2·C7H8O3S·2H2O=766.85(as Anhydrous)
CAS RN 83105-70-8
Related CAS RN 76497-13-7
MDL Number MFCD01682151
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Purity(HPLC) min. 98.0 area%
Purity(with Total Nitrogen) min. 98.0 %(calcd.on anh.substance)
Specific rotation [a]20/D +168 to +186 deg(C=0.5, water/CH3CN 3:2)


Reaxys-RN 25499733
PubChem SID 354335315
Merck Index(14) 8992
RTECS# XH8460000

Transport Information

HS Number 2941.10.5000


Sultamicillin Tosylate: The Mutual Prodrug of Ampicillin and Sulbactam

Sultamicillin tosylate is a double ester mutual prodrug in which ampicillin [A2092] and the β-lactamase inhibitor sulbactam [S0868] are linked via a methylene group. Sultamicillin is readily absorbed and hydrolyzed by enzymes in the intestinal wall, releasing ampicillin and sulbactam. Ampicillin is an aminopenicillin which exerts its bactericidal activity by inhibiting transpeptidase, an enzyme responsible for the synthesis of the peptidoglycan layer of the bacterial cell wall. Sulbactam is an irreversible inhibitor of many plasmid-mediated and some chromosomal β-lactamases, produced by resistant bacteria. Therefore, sultamicillin is effective against a wide range of gram-positive and gram-negative bacteria including Staphylococcus aureus and Staphylococcus epidermidis, including penicillin-resistant and some methicillin-resistant strains. (The product is for research purpose only.)


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