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Sulfisoxazole
(CAS RN:127-69-5 Product Number:U0098)

Structure

Sulfisoxazole
Synonym 4-Amino-N-(3,4-dimethyl-5-isoxazolyl)benzenesulfonamide
Synonym Sulfafurazole

General Information

Product Number U0098

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Purity/Analysis Method >98.0%(HPLC)
Storage Temperature 0-10°C
M.F. / M.W. C11H13N3O3S=267.30
CAS RN 127-69-5
Related CAS RN
MDL Number MFCD00003150
  • Product Details
  • Safety & Regulations
  • Reference & Application

Specification

Purity(HPLC) min. 98.0 area%
Purity(Neutralization titration) min. 98.0 %
Melting point 193.0 to 197.0 deg-C

Data of Reference

λmax 271(MeOH)(lit.)

References

Reaxys-RN 263871
PubChem SID 354335300
Merck Index(14) 8952
RTECS# WO9100000

GHS

Pictogram
Signal Word Warning
Hazard Statements
  • H315
  • :Causes skin irritation.
  • H319
  • :Causes serious eye irritation.
Precautionary Statements
  • P264
  • :Wash hands and face thoroughly after handling.
  • P280
  • :Wear protective gloves, eye protection.
  • P302+P352+P332+P313+P362+P364
  • :If on skin: Wash with plenty of soap and water. If skin irritation occurs: Get medical advice or attention. Take off contaminated clothing and wash it before reuse.
  • P305+P351+P338+P337+P313
  • :If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice or attention.

Transport Information

HS Number 2935.90.4800

Application

Sulfisoxazole: A Sulfonamide Antimicrobial

Sulfisoxazole is a sulfonamide antimicrobial which inhibits bacterial synthesis of dihydrofolic acid (DHF) which is needed to make both purines and pyrimidines, are constituents of DNA and RNA. Sulfonamide antimicrobials structurally resemble 4-aminobenzoic acid (PABA)[A0269], a precursor in bacterial DHF synthesis. Therefore, sulfonamide antimicrobials completely inhibit utilization of PABA and synthesis of DHF, and they possess bacteriostatic activity against a broad spectrum of pathogens. Recently, some new antimicrobials bearing sulfisoxazole moiety have been reported.

References

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