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Trifluoroacetic Acid
(CAS RN:76-05-1 Número do Produto:T0431)


Trifluoroacetic Acid
Sinônimo TFA

Informações Gerais

Número do Produto T0431

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Pureza/Método de Análise >99.0%(T)
Temperatura de armazenamento
M.F. / M.W. C2HF3O2=114.02
CAS RN 76-05-1
CAS RN Relacionado
Número MDL MFCD00004169
  • Informações Sobre o Produto
  • Segurança & Regulamentos
  • Referência & Aplicação


Purity(Neutralization titration) min. 99.0 %
Specific gravity (20/20) 1.4910 to 1.4950

Dados de Referência

bp 73°C


Beilstein 2(4)458
Reaxys-RN 742035
PubChem SID 87576383
Merck Index(14) 9681
F&F 9,483
RTECS# AJ9625000


Palavra de sinal Danger
Propriedades Perigosas & Prejudiciais
  • H290
  • :May be corrosive to metals.
  • H301
  • :Toxic if swallowed.
  • H314
  • :Causes severe skin burns and eye damage.
  • H332
  • :Harmful if inhaled.
  • H412
  • :Harmful to aquatic life with long lasting effects.
  • P234
  • :Keep only in original container.
  • P260
  • :Do not breathe dusts or mists.
  • P264
  • :Wash hands and face thoroughly after handling.
  • P270
  • :Do not eat, drink or smoke when using this product.
  • P271
  • :Use only outdoors or in a well-ventilated area.
  • P273
  • :Avoid release to the environment.
  • P280
  • :Wear protective gloves, protective clothing, face protection.
  • P301+P330+P331+P310
  • :If swallowed: Rinse mouth. Do NOT induce vomiting. Immediately call a poison center or doctor.
  • P303+P361+P353+P310+P363
  • :If on skin (or hair): Take off immediately all contaminated clothing. Rinse skin with water or shower. Immediately call a poison center or doctor. Wash contaminated clothing before reuse.
  • P304+P340+P310
  • :If inhaled: Remove person to fresh air and keep comfortable for breathing. Immediately call a poison center or doctor.
  • P305+P351+P338+P310
  • :If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a poison center or doctor.
  • P390
  • :Absorb spillage to prevent material damage.
  • P405
  • :Store locked up.
  • P406
  • :Store in corrosive resistant bottle or metal container with a resistant inner liner.
  • P501
  • :Dispose of contents and container in accordance with local, regional, national regulations (e.g. US: 40 CFR Part 261, EU:91/156/EEC, JP: Waste Disposal and Cleaning Act, etc.).

Informações de transporte

Número ONU 2699
Classe 8
Materiais perigosos I
Número SH 2915.90.1800


Deprotection of MOM Groups using Trifluoroacetic Acid


  • Protection for the Hydroxyl Group, Including 1,2- and 1,3-Diols
    • P. G. M. Wuts, in Greene’s Protective Groups in Organic Synthesis, 5th ed., ed. by P. G. M. Wuts, John Wiley & Sons, Inc., Hoboken, New Jersey, 2014, Chap. 2, 17.

Pfitzner-Moffat Oxidation

Typical Procedure:
To a stirred solution of alcohol 1 (913 mg, 3.06 mmol) in benzene (85 mL) are added DMSO (1.31 mL, 18.4 mmol), pyridine (0.37 mL, 4.6 mmol), CF3COOH (0.35 mL, 4.6 mmol), and dicyclohexylcarbodiimide (1.89 g, 9.2 mmol). After being stirred for 30 min, the resulting white solids are filtered off. The filtrate is diluted with AcOEt (500 mL), and this is wshed with H2O (100 mL). The organic phase is dried over Na2SO4 and concentrated in vacuo. To the residue is added a small amount of AcOEt, and the precipitates are filtered off. The filtrate is concentrated in vacuo to give crude tetrahydrofuranone 2, which is reduced directly. The residue is dissolved in MeOH (20 mL), and NaBH4 (174 mg, 4.6 mmol) is added. After being stirred for 1 h, the mixture is neutralized with Amberlite IR-120 (H+). The resin is removed by filtration and washed with MeOH. The combined filtrate and washings are concentrated in vacuo. The residue is purified by flash column chromatography (SiO2, AcOEt : Toluene = 1 : 20) to give the epi alcohol 3 (758 mg, Y. 83%) as white crystals.


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