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Brefeldin A
(CAS RN:20350-15-6 產品號碼:B3820)

結構式

Brefeldin A
別名 (英文) Ascotoxin
別名 (英文) Cyanein
別名 (英文) Decumbin
別名 (英文) γ,4-Dihydroxy-2-(6-hydroxy-1-heptenyl)-4-cyclopentanecrotonic Acid λ-Lactone

基本信息

產品號碼 B3820

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純度/分析方法 >98.0%(HPLC)
儲藏溫度 <0 °C
分子式 / 分子量 C16H24O4=280.36
CAS RN 20350-15-6
相關CAS RN
MDL號碼 MFCD12913297
包裝
  • 產品詳細信息
  • 安全&法規
  • 文獻&應用

規格

Purity(HPLC)(CAD) min. 98.0 area%
Elemental analysis(Carbon) 65.50 to 71.50 %

參考值

mp 204°C(lit.)
[α]20D 93° (C=2,MeOH)(lit.)
λmax 215(EtOH)(lit.)

文獻

Reaxys-RN 25191
Merck Index(14) 1369
RTECS# GY8410000

GHS

圖形表示
提示語 Danger
危險有害信息
  • H301
  • :Toxic if swallowed.
注意
  • P264
  • :Wash hands and face thoroughly after handling.
  • P270
  • :Do not eat, drink or smoke when using this product.
  • P301+P310+P330
  • :If swallowed: Immediately call a poison center or doctor. Rinse mouth.
  • P405
  • :Store locked up.
  • P501
  • :Dispose of contents and container in accordance with local, regional, national regulations (e.g. US: 40 CFR Part 261, EU:91/156/EEC, JP: Waste Disposal and Cleaning Act, etc.).

交通信息

 UN 號碼 2811
類別 6.1
聯合國包裝等級 III

應用

Brefeldin A: A Macrolide Lactone Antibiotic used as an Inhibitor of Protein Trafficking and Secretion

Brefeldin A (BFA) is a natural fungal macrolide lactone antibiotic. Studies has demonstrated that BFA reversibly interferes with protein trafficking and secretion mediated by the Golgi apparatus and endoplasmic reticulum. Therefore, BFA has been used as a tool to inhibit protein secretion and study the secretory pathway, effects of BFA on Golgi apparatus and other subcellular systems.

References

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