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Dimethyl (1-Diazo-2-oxopropyl)phosphonate
(CAS RN:90965-06-3 產品號碼:D3546)

結構式

Dimethyl (1-Diazo-2-oxopropyl)phosphonate
別名 (英文) 1-Diazoacetonylphosphonic Acid Dimethyl Ester
別名 (英文) (1-Diazo-2-oxopropyl)phosphonic Acid Dimethyl Ester
別名 (英文) Dimethyl 1-Diazoacetonylphosphonate
別名 (英文) Ohira-Bestmann Reagent

基本信息

產品號碼 D3546

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純度/分析方法 >97.0%(HPLC)
儲藏溫度 0-10 °C
分子式 / 分子量 C5H9N2O4P=192.11
CAS RN 90965-06-3
相關CAS RN
MDL號碼 MFCD07368360
包裝
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  • 安全&法規
  • 文獻&應用

規格

Purity(HPLC) min. 97.0 area%
Specific gravity (20/20) 1.2680 to 1.2820
Refractive index n20/D 1.4770 to 1.4820

文獻

Reaxys-RN 4247670
PubChem SID 87559944
Merck Index(14) 1177

應用

Synthesis of Phosphonyl Pyrazoles

Typical Procedure: To a stirred solution of aldehyde (1 mmol), cyanoacid derivative (1.2 mmol) and Ohira-Bestmann reagent (1.5 mmol) in distilled MeOH (4 mL), is added molecular sieves followed by powdered KOH (2 mmol). The reaction mixture is stirred at room temperature for one hour. After the completion of the reaction (TLC monitoring), methanol is distilled off under reduced pressure. The crude residue is dissolved in ethyl acetate (50 mL) and washed with saturated ammonium chloride (2×20 mL). Finally the organic layer is washed with saturated brine (20 mL) and dried over anhydrous sodium sulphate. After removal of the solvent, column chromatographic purification is carried out using acetone-dichloromethane as eluent to afford the products.

References

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