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Pyridinium p-Toluenesulfonate
(CAS RN:24057-28-1 產品號碼:P0942)

結構式

Pyridinium p-Toluenesulfonate
別名 (英文) PPTS

基本信息

產品號碼 P0942

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純度/分析方法 >98.0%(T)
儲藏溫度
分子式 / 分子量 C5H5N·C7H8O3S=251.30
CAS RN 24057-28-1
相關CAS RN
MDL號碼 MFCD00013108
包裝
  • 產品詳細信息
  • 安全&法規
  • 文獻&應用

規格

Purity(Neutralization titration) min. 98.0 %
Melting point 118.0 to 122.0 deg-C
Solubility in Water almost transparency

文獻

Beilstein 20(2)129
Reaxys-RN 3764305
PubChem SID 87575059
F&F 9,400

GHS

提示語 Warning
危險有害信息
  • H320
  • :Causes eye irritation.
注意
  • P264
  • :Wash hands and face thoroughly after handling.
  • P305+P351+P338+P337+P313
  • :If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice or attention.

應用

Application for Introduction of Protecting Groups Using PPTS as an Acid Catalyst

P0942

Typical procedure :PPTS catalyzed THP protection of (R)-(+)-glycidol
Pyridinium p-toluenesulfonate (PPTS) (1.00 g, 4.05 mmol) and 3,4-dihydro-2H-pyran (11.3 mL, 121.5 mmol) are added to a stirred solution of (R)-(+)-glycidol (6.00 g, 80.99 mmol) in dichloromethane (80 mL) at 0 ºC under argon atmosphere. After 6 h, aqueous NaHCO3 solution (60 mL) is added and the layers are separated. The aqueous layer is extracted with dichloromethane (3x50 mL). Combined organic layer is dried over MgSO4, filtered, and concentrated in vacuo. The crude mixture is purified by column chromatography (EtOAc:hexane = 1:5) to give the desired product (9.22 g, 72%).

References

PPTS Catalyzed Hydrolysis of Dioxolane-type Acetals

References

PubMed Literature

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