In the context of protecting groups, "caged" compounds refer to protecting groups bonded to bioactive molecules that can be readily removed in an orthogonal manner. The "caging" of bioactive molecule with photolabile protecting groups in particular have proven to be a particularly useful tool in biochemical research. Caged compounds in which bioactive substances are inactivated with photolabile protecting groups1) and can be activated by UV or visible light photoirradiation. Research towards controlling the topical expression of biomolecule activity using caged compounds has been recently reported and continues to be heavily investigated. To date, several classes of caged biomolecule have been synthesized and reported, including: nucleotides,1) amino acids,2) biotin,3) and sugars.4)
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光分解保护基 / Photolabile Protecting Groups
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- 2)R. Wieboldt, K. R. Gee, L. Niu, D. Ramesh, B. K. Carpenter, G. P. Hess, P. Natl. Acad. Sci. USA 1994, 91, 8752.
- 3)T. Terai, E. Maki, S. Sugiyama, Y. Takahashi, H. Matsumura, Y. Mori, T. Nagano, Chem. Biol. 2011, 18, 1261.
- 4)C. Bier, D. Binder, D. Drobietz, A. Loeschcke, T. Drepper, K.-E. Jaeger, J. Pietruszka, Synthesis 2017, 49, 42.