Normally a time and material consuming process, whole-body clearing with TCI is achieved using our ground-breaking CUBIC reagents. In all, we offer 7 clearing reagents for whole-organ/body imaging at a cellular resolution. Being a hydrophilic vs. a hydrophobic method, the process requires no special equipment, cuts sample treatment time, and offers a low quenching fluorescence signal. Click below for the TCI Technical CUBIC Guide that shows the full suite of clearing reagents and their use, protocols, and much more.
With several sugar-conjugates available, TCI offers market-leading carbohydrate-conjugated human serum albumin (HSA) manufactured with synthesized, high-purity carbohydrates. Additionally, TCI offers synthesis of monosaccharide and oligosaccharide derivatives with custom synthesis service for sugar compounds that are not commercially available.
Non-RTKs are cytosolic TK enzymes with no transmembrane domein and whose activity is regulated by other cell surface factors, or within the cytoplasm (while transmitting signals). Mutations within genes for non-RTKs (including BCR-ABL), can result in an aberrant activity of this enzyme; pathologically increased activity of non-RTK may be responsible for growth of malignances, the induction of drug-resistance, and formation of metastasis. Non-RTKs are regarded as important targets in development of anti-tumor agents.
Humans cannot synthesize N-Glycolylneuraminic Acid (Neu5Gc) due to a mutation in the gene encoding the enzyme responsible for Neu5Gc synthesis. Humans naturally possess antibodies against Neu5Gc glycan structures, and this is responsible for the immunogenicity of therapeutic proteins containing Neu5Gc glycan epitopes. Therefore, a antibody for the detection of Neu5Gc is required.
On the other hands, binding of anti-αGal antibody (in humans) to αGal antigens (αGal epitope, a carbohydrate) expressed on porcine xenograft surfaces are a major factor for determining engraft survival. Recently, it has been observed that therapeutic antibodies and cell processing material for reproductive medicine contain the αGal epitope, which indicates the importance of rapid detection of αGal epitope.
So, TCI offers Anti-NeuGc Polyclonal Antibody [A3240] and Anti-αGal Polyclonal Antibody [A3123] and etc.
* The prices displayed in the landing website are USD based catalog prices. TCI has specific website and local currency based price list for customers in South Korea, Singapore, and Australia. For customers in other Asia Pacific countries / regions, please visit our Asia Pacific Website and contact our local distributors for the end user's cost. (The USD prices that are shown in Asia Pacific websites are TCI's catalog prices.)
Please visit each country/region's website from the following links and confirm the prices.https://www.TCIchemicals.com