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Osteogenic Differentiation Promoting Agent

The helioxanthin analogue (TH) is an osteogenic small compound that was first reported by Ohba et al.1) In their reports, TH not only stimulates osteoblast differentiation of osteoblast precursors, but also enhances bone regeneration in rodent bone defect models.2,3) The osteogenic effects are also observed in mouse and human pluripotent stem cells4,5) as well as human dental pulp stem cells.6)

Osteogenic_Differentiation_Promoting_Agent

Advantages

• Stimulates osteoblast differentiation of osteoblast precursors
• Enhances bone regeneration in rodent bone defect models
• Induces the osteogenic effects on stem cells

Applications

Figure 1. mRNA expression of osteoblast marker genes
in MC3T3-E1 cells treated with TH for 14 days (RT-qPCR analysis).

Figure 2. ALP staining of MC3T3-E1 cells treated with TH for 14 days.

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References

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