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Gilman Reaction

 Gilman reaction is a name reaction as typified by 1,4-additions of α,β-unsaturated ketones as well as SN2-type alkylation of alkyl halides. Gilman reagents are organocopper compounds typically illustrated by C-Cu-C core with a lithium counterion and are particularly useful for the Gilman reaction. The reagents are readily preparable from 2 equiv. of alkyllithium reagents and a copper(I) salt such as CuI.



Reagents: Gilman reagents
Reactants: α,β-unsaturated carbonyl compounds, alkyl halides
Products: corresponding adducts

Scheme:

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