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CAS RN: 91421-43-1 | Product Number: A2063
9-Aminocamptothecin
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Purity: >95.0%(HPLC)
Synonyms:
Product Documents:
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| 10MG |
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| Product Number | A2063 |
| Purity / Analysis Method | >95.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__0H__1__7N__3O__4 = 363.37 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 91421-43-1 |
| Reaxys Registry Number | 4276593 |
| PubChem Substance ID | 87560557 |
| Merck Index (14) | 431 |
| MDL Number | MFCD00909855 |
Specifications
| Appearance | Light yellow to Yellow to Orange powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| NMR | confirm to structure |
Properties (reference)
GHS
Related Laws:
| RTECS# | UQ0490500 |
Transport Information:
| H.S.code* | 2939.79-000 |
Application
9-Aminocamptothecin (9-AC): A Water Insoluble Topoisomerase-I Inhibitor
9-Aminocamptothecin (9-AC) is a water insoluble derivative of camptothecin [C1495] with broad antitumor activity, and a metabolite of 9-nitrocamptothecin [N0822]. Camptotecin and its derivatives interfere with DNA synthesis by inhibiting the enzyme topoisomerase-I. In order to prevent and correct of topological problems caused by the DNA double helix, topoisomerase-I catalyzes the relaxation of negatively supercoiled DNA, the knotting and unknotting DNA and the linking complementary rings of single-stranded DNA into double-stranded rings. Then the inhibition action induces breaks in single strand DNA. Eventually, this leads to double-strand DNA breaks and apoptosis or cell death.
References
- Plant antitumor agents. 30. Synthesis and structure activity of novel camptothecin analogs
- Comparison of topoisomerase I inhibition, DNA damage, and cytotoxicity of camptothecin derivatives presently in clinical trials
- The clinical development of 9-Aminocamptothecin (a review)
- The camptothecins (a review)
- Analysis of the active lactone form of 9-aminocamptothecin in plasma using solid-phase extraction and high-performance liquid chromatography
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