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CAS RN: 7177-48-2 | 产品编码: A2092
Ampicillin Trihydrate
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This product has not been tested for potency and is guaranteed for chemical purity.
技术规格
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 %(calcd.on anh.substance) |
| Specific rotation [a]20/D | +280.0 to +305.0 deg(C=0.5, H2O)(calcd.on anh.substance) |
| Water | 12.0 to 15.0 % |
物性（参考值）
| 熔点 | 202 °C(dec.) |
| 比旋光度 [α]D | 293° (C=0.5,H2O) |
| 在水中的溶解度 | 10 g/l 21 °C |
| 溶解性（不溶于） | 乙醚, 氯仿, 苯 |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. H362 : May cause harm to breast-fed children. |
| 防范说明 | P263 : Avoid contact during pregnancy and while nursing. P260 : Do not breathe dust. P270 : Do not eat, drink or smoke when using this product. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
相关法规
| RTECS# | XH8425000 |
运输信息
| HS编码* | 2941.10-000 |
应用
Ampicillin: The First of Broad Spectrum Penicillins
Ampicillin, a penicillin-like antibiotic, is enzymatic synthesized from 6-APA [A0800] catalyzed by penicillin acylase. Ampicillin is the first of a number of so-called broad spectrum penicillins. That amino group helps the drug penetrate the outer membrane of Gram-negative bacteria. Thus, ampicillin has activity against not only Gram-positive bacteria such as Staphylococci and Streptococci but also Gram-negative bacteria such as H. influenzae, coliforms and Proteus species. It acts as a competitive inhibitor of the enzyme transpeptidase, which is needed by bacteria to make their cell walls. Its spectrum of activity is enhanced by co-administration of sulbactam [S0868], a drug that inhibits beta lactamase an enzyme produced by bacteria to inactivate ampicillin. Ampicillin is used in molecular biology as a selective reagent most commonly to isolate bacteria coupled to a gene coding for ampicillin resistance, which is one of the most frequently used selection markers for obtaining transgenic cells.
References
- Ampicillin [D-6-(2-amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid] (a review)
- Sulbactam/ampicillin. A review of its antibacterial activity, pharmacokinetic properties, and therapeutic use
- Ampicillin-sulbactam: an update on the use of parenteral and oral forms in bacterial infections
- Construction and characterization of new cloning vehicle. II. A multipurpose cloning system
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