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CAS RN: 164178-33-0 | Product Number: A3160
AM-630
×
Purity: >98.0%(HPLC)
Synonyms:
- Iodopravadoline
- [6-Iodo-2-methyl-1-(2-morpholinoethyl)-1H-indol-3-yl](4-methoxyphenyl)methanone
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 25MG |
$249.00
|
9 | 1 | It can be shipped in about 2 weeks after ordering |
* Please contact our distributors or
TCI
to order our products. The above prices do not include freight cost, customs, and other charges to the destination.
* The storage conditions are subject to change without notice.
| Product Number | A3160 |
Purity / Analysis Method 
|
>98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__3H__2__5IN__2O__3 = 504.37 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 164178-33-0 |
| Reaxys Registry Number | 8360417 |
| MDL Number | MFCD01861183 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 143.0 to 147.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 147 °C |
GHS
Related Laws:
Transport Information:
| H.S.code* | 2934.99-000 |
Application
AM-630: A CB2 Receptors Selective Antagonist
AM-630 is a cannabinoid 2 (CB2) receptors selective antagonist and as a weak partial agonist at CB1 receptors.1) Cannabinoid receptors, located throughout the body, are part of the endocannabinoid system (ECS) which is involved in a variety of physiological processes. There are two types of cannabinoid receptors, CB1 and CB2. One of them, CB2 receptors are mainly expressed only during active inflammation and do not show undesirable psychotropic or addictive effects. Therefore, drug discovery research targeting CB2 receptors is underway for neurodegenerative diseases such as neuropathic pain and Alzheimer's disease. Therefore, AM-630 has been used as an important reagent for CB2 receptors research.2-4) (The product is for research purpose only.)
References
- 1) Agonist-inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656 and AM630
- 2) Pharmacological actions of cannabinoids (a review)
- 3) Brain cannabinoid CB2 receptors modulate cocaine's actions in mice
- 4) Anti-inflammatory effects of cannabinoid CB2 receptor activation in endotoxin-induced uveitis
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