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CAS RN: 24390-14-5 | 产品编码: D4116
Doxycycline Hyclate
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| 产品编码 | D4116 |
纯度/分析方法 
|
>97.0%(HPLC) |
| 分子式/分子量 | C__2__2H__2__4N__2O__8·^^1/__2C__2H__6O·HCl·^^1/__2H__2O = 512.94 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
室温 (15°C以下阴凉干燥处) |
| CAS RN | 24390-14-5 |
| 相关CAS RN
|
10592-13-9&564-25-0 |
| PubChem物质ID | 172089114 |
| Merck Index (14) | 3440 |
| MDL编号 | MFCD07357237 |
技术规格
| Appearance | Light yellow to Amber to Dark green powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(Nonaqueous Titration) | min. 95.0 % |
| Specific rotation [a]20/D | -100 to -107 deg(C=1, 0.01mol/L HCl(MeOH)) |
| Water | 1.4 to 2.8 % |
| Ethanol(NMR) | 4.3 to 6.0 % |
物性（参考值）
| 比旋光度 [α]D | -104° (C=1,0.01mol/L HCl(MeOH)) |
GHS
| 象形图 |
|
| 信号词 | Warning |
| 危险性说明 | H361 : Suspected of damaging fertility or the unborn child. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
相关法规
运输信息
| HS编码* | 2941.30-000 |
应用
Gingipain inhibitor
Doxycycline has been reported to inhibit gingipains, RgpB, HRgpA, (IC50 : about 3 μM, respectively) and Kgp (IC50 : about 20 μM) from Porphyromonas gingivalis.1) The Ki value of the compound to RgpB is 54 μM.
(The product is for research purpose only.)
(The product is for research purpose only.)
Reference
- 1) Inhibition of Trypsin-Like Cysteine Proteinases (Gingipains) from Porphyromonas gingivalis by Tetracycline and Its Analogues
- Doxycycline revisited
- Development and evaluation of novel biodegradable microspheres based on poly(D,L-lactide-co-glycolide) and poly(ε-caprolactone) for controlled delivery of doxycycline in the treatment of human periodontal pocket: In vitro and in vivo studies
- Subantimicrobial dose doxycycline as adjunctive treatment for periodontitis.
- Subantimicrobial dose doxycycline as an adjunct to scaling and root planing: Post-treatment effects
- Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice
- Exploring the sequence space for tetracycline-dependent transcriptional activators: novel mutations yield expanded range and sensitivity
- piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells
- Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector
- Transcriptional activation by tetracyclines in mammalian cells
- M. Gossen, S. Freundlieb, G. Bender, G. Muller, W. Hillen, H. Bujard, Science 1995, 268, 1766.
应用
Studies on the Antibacterial Activity of Doxycycline
References
应用
Applications of Doxycycline to Biogenetics Studies
References
PubMed Literature
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