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Published TCIMAIL newest issue No.200 | Product Document Searching Made Easy by 2D Code! | [TCIPracticalExample] Suzuki-Miyaura Coupling Using Encapsulated...

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CAS RN: 78287-27-1 | Product Number: E0781

7-Ethylcamptothecin

Purity: >98.0%(T)(HPLC)

Synonyms:

Product Documents:

Size	Unit Price	Hyderabad	Japan*	Quantity
100MG	₹7,000.00	Contact Us	16
1G	₹16,600.00	Contact Us	8

*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.

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General Information plus

Specifications & Properties plus

Specifications

Appearance	Light orange to Yellow to Green powder to crystal
Purity(HPLC)	min. 98.0 area%
Purity(Nonaqueous Titration)	min. 98.0 %
Specific rotation [a]20/D	+40.0 to +46.0 deg(C=0.4, CHCl3:MeOH=8:2)

Properties (reference)

Specific Rotation

43° (C=0.4,CHCl3:MeOH=8:2)

Safety & Regulations plus

GHS

Pictogram
Signal Word	Danger
Hazard Statements	H301 + H311 + H331 : Toxic if swallowed, in contact with skin or if inhaled.
Precautionary Statements	P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing. P361 + P364 : Take off immediately all contaminated clothing and wash it before reuse. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water.Call a POISON CENTER/doctor if you feel unwell. P304 + P340 + P311 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. P405 : Store locked up.

Related Laws:

Transport Information:

UN Number	UN1544
Class	6.1
Packing Group	III

Applications & Literature plus

Application

7-Ethylcamptothecin: A Water Insoluble Topoisomerase-I Inhibitor

7-Ethylcamptothecin (SN-22) is a water insoluble derivative of camptothecin [C1495] with broad antitumor activity. 7-Ethylcamptothecin has been converted into water soluble derivatives such as irinotecan hydrochloride [I0714]. Camptotecin and its derivatives interfere with DNA synthesis by inhibiting the enzyme topoisomerase-I. In order to prevent and correct of topological problems caused by the DNA double helix, topoisomerase-I catalyzes the relaxation of negatively supercoiled DNA, the knotting and unknotting DNA and the linking complementary rings of single-stranded DNA into double-stranded rings. Then the inhibition action induces breaks in single strand DNA. Eventually, this leads to double-strand DNA breaks and apoptosis or cell death.

References

Action of 7-ethylcamptothecin on tumor cells and its disposition in mice
- H. Nagata, N. Kaneda, T. Furuta, S. Sawada, T. Yokokura, T. Miyasaka, M. Fukada, K. Notake, Cancer Treat. Rep. 1987, 71, 341.
Antitumor activity of a new camptothecin derivative, SN-22, against various murine tumors
- T. Kunimoto, K. Nitta, T. Tanaka, N. Uehara, H. Baba, M. Takeuchi, T. Yokokura, S. Sawada, T. Miyasaka, M. Mutai, J. Pharmacobio-Dyn. 1987, 10, 148.
Chemical Modification of an Antitumor Alkaloid Camprothecin : Synthesis and Antitumor Activity of 7-C-Substituted Camptothecins
- S. Sawada, K. Nokata, T. Furuta, T. Yokokura, T. Miyasaka, Chem. Pharm. Bull. 1991, 39, 2574.
The thermodynamic dissociation constants of the anticancer drugs camptothecine, 7-ethyl-10-hydroxycamptothecine, 10-hydroxycamptothecine and 7-ethylcamptothecine by the least-squares nonlinear regression of multiwavelength spectrophotometric pH-titration data
- M. Meloun, S. Bordovská, A. Vránab, Anal. Chim. Acta 2007, 584, 419.
14-Aminocamptothecins: Their Synthesis, Preclinical Activity, and Potential Use for Cancer Treatment
- J.-X. Duan, X. Cai, F. Meng, J. D. Sun, Q. Liu, D. Jung, H. Jiao, J. Matteucci, B. Jung, D. Bhupathi, D. Ahluwalia, H. Huang, C. P. Hart, M. Matteucci, J. Med. Chem. 2011, 54, 1715.

PubMed Literature

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Safety Data Sheet (SDS)

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Specifications

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Analytical Charts

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Product Number	E0781
Purity / Analysis Method	>98.0%(T)(HPLC)
Molecular Formula / Molecular Weight	C__2__2H__2__0N__2O__4 = 376.41
Physical State (20 deg.C)	Solid
Storage Temperature	Room Temperature (Recommended in a cool and dark place, <15°C)
CAS RN	78287-27-1
Reaxys Registry Number	4828556
PubChem Substance ID	87561055
MDL Number	MFCD06657922

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CAS RN: 78287-27-1 | Product Number: E0781