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Published TCIMAIL newest issue No.199
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CAS RN: 53179-09-2 | Product Number: I1049
Sisomicin Sulfate
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Purity: >98.0%(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 250MG |
€41.00
|
Contact Us | Contact Us |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | I1049 |
Purity / Analysis Method 
|
>98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__9H__3__7N__5O__7·2^^1/__2H__2SO__4 = 692.71 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 53179-09-2 |
| Related CAS RN
|
32385-11-8 |
| Reaxys Registry Number | 5709343 |
| PubChem Substance ID | 354335157 |
| Merck Index (14) | 8550 |
| MDL Number | MFCD00058308 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Specific rotation [a]20/D | +98.0 to +104.0 deg(C=1, H2O) |
Properties (reference)
| Melting Point | 73 °C |
| Boiling Point | 155 °C |
| Specific Rotation | 100° (C=1,H2O) |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H360 : May damage fertility or the unborn child. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
Related Laws:
| EC Number | 258-414-4 |
Transport Information:
| HS Number | 2941900000 |
Application
Sisomicin Sulfate: An Aminoglycoside Antibiotic that is Effective against Pseudomonas aeruginosa
Sisomicin sulfate is a naturally occurring aminoglycoside antibiotic produced by Micromonospora inyoensis. Sisomicin is bactericidal in action against a wide range of Gram-negative and Gram-positive bacteria, including Klebsiella species, Escherichia coli, Pseudomonas aeruginosa, Enterobacter species, and Proteus species. Sisomicin is closely related structurally to gentamicin [G0383], but in vitro studies have shown it to have superior activity to gentamicin against Pseudomonas aeruginosa. Sisomicin, like that of the other aminoglycoside antibiotics, binds the 30s ribosomal subunit, causing misreading of the mRNA sequence and inhibition of transcription. Consequently, bacterial protein synthesis is inhibited. (The product is for research purpose only.)
References
- Activity of five aminoglycoside antibiotics in vitro against gram-negative bacilli and Staphylococcus aureus
- Sisomicin, netilmicin and dibekacin: a review of their antibacterial activity and therapeutic use
- Sisomicin: an aminoglycoside antibiotic that is highly effective against Pseudomonas (a review)
- High-performance liquid chromatographic analysis of aminoglycoside antibiotics
PubMed Literature
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