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CAS RN: 24386-93-4 | Product Number: I1156
5-Iodotubercidin
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 7-Deaza-7-iodoadenosine
- 5-Iodo-7-β-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
- 4-Amino-5-iodo-7-β-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidine
- 7-Iodo-7-deazaadenosine
Product Documents:
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| 200MG |
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| Product Number | I1156 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__1H__1__3IN__4O__4 = 392.15 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 24386-93-4 |
| Reaxys Registry Number | 4543232 |
| MDL Number | MFCD00055131 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Volumetric Analysis) | min. 98.0 % |
| NMR | confirm to structure |
Properties (reference)
| Maximum Absorption Wavelength | 284 nm (MeOH) |
GHS
Related Laws:
Transport Information:
| H.S.code* | 2934.99-000 |
Application
5-Iodotubercidin: A General Protein Kinase Inhibitor
5-Iodotubercidin is a potent and competitive adenosine protein kinase inhibitor. It has been reported that 5-iodotubercidin inhibits CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2, PKC, and nucleoside transporter.1-3) 5-iodotubercidin also inhibits LRRK2 (Leucine-rich repeat kinase 2) –G2019S that is a promising therapeutic target for the treatment of Parkinson's disease.4) There is a recent report, that 5-Iodotubercidin inhibits SARS-CoV-2 RNA-dependent RNA polymerase (RdRp).5) (The product is for research purpose only.)
References
- 1) Identification of the glycogenic compound 5-iodotubercidin as a general protein kinase inhibitor
- 2) Effects of iodotubercidin on adenosine kinase activity and nucleoside transport in DDT MF-2 smooth muscle cells
- 3) Adenosine Kinase Inhibitors. 1. Synthesis, Enzyme Inhibition, and Anti-seizure Activity of 5-Iodotubercidin Analogue
- 4) Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease
- 5) 5-Iodotubercidin inhibits SARS-CoV-2 RNA synthesis
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