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Published TCIMAIL newest issue No.198
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CAS RN: 404-86-4 | Product Number: M1149
Capsaicin (Natural)
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Purity: >60.0%(HPLC)
Synonyms:
- N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide
- 8-Methyl-N-vanillyl-6-nonenamide
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
€59.00
|
3 | 31 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | M1149 |
Purity / Analysis Method 
|
>60.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__8H__2__7NO__3 = 305.42 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 404-86-4 |
| Reaxys Registry Number | 2816484 |
| PubChem Substance ID | 87573112 |
| Merck Index (14) | 1768 |
| MDL Number | MFCD00017259 |
Specifications
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 60.0 area% |
| Total Nitrogen | 4.3 to 4.8 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 65 °C |
| Solubility (soluble in) | Ethanol, Chloroform |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H300 : Fatal if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. |
Related Laws:
| EC Number | 206-969-8 |
| RTECS# | RA8530000 |
Transport Information:
| UN Number | UN3462 |
| Class | 6.1 |
| Packing Group | II |
| HS Number | 2924297099 |
Application
Efflux pump inhibitor
References
- Capsaicin, a novel inhibitor of the NorA efflux pump, reduces the intracellular invasion of Staphylococcus aureus
Application
Reagent for pain model
References
- Activation of the cAMP transduction cascade contributes to the mechanical hyperalgesia and allodynia induced by intradermal injection of capsaicin
- Stimulation of deep somatic tissue with capsaicin produces long-lasting mechanical allodynia and heat hypoalgesia that depends on early activation of the cAMP pathway
- Comparison of antinociceptive actions of standard analgesics in attenuating capsaicin and nerve-injury-induced mechanical hypersensitivity
- Increased spinal release of excitatory amino acids following intradermal injection of capsaicin is reduced by a protein kinase G inhibitor
- Role of protein kinase A in phosphorylation of NMDA receptor 1 subunits in dorsal horn and spinothalamic tract neurons after intradermal injection of capsaicin in rats
- Capsaicin-induced sensitization of primate spinothalamic tract cells is prevented by a protein kinase C inhibitor
- Inhibitors of G-proteins and protein kinases reduce the sensitization to mechanical stimulation and the desensitization to heat of spinothalamic tract neurons induced by intradermal injection of capsaicin in the primate
- A new model of visceral pain and referred hyperalgesia in the mouse
Application
Reagent for coughing model
References
- Mechanisms of capsaicin- and citric-acid-induced cough reflexes in guinea pigs
- Animal models of cough: literature review and presentation of a novel cigarette smoke-enhanced cough model in the guinea-pig
- Dynamic modelling of a challenge-escalation cross-over study of treatment of capsaicin-induced coughing
Application
Reagent for acute inflammatory (ear edema) model
Reference
- Profile of capsaicin-induced mouse ear oedema as neurogenic inflammatory model: comparison with arachidonic acid-induced ear oedema
PubMed Literature
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