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CAS RN: 159989-65-8 | Product Number: N0986
Nelfinavir Mesylate
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Purity: >97.0%(HPLC)
Synonyms:
- Nelfinavir Methanesulfonate
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 25MG |
163,00 €
|
1 | 3 |
|
|
| 100MG |
449,00 €
|
2 | 5 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
Supplemental Product Information:
Previously this product had been labeled as a hydrate form both in product name and molecular formula. The hydrate form had no exclusive CAS RN and used to share the same CAS RN as the anhydrous form.
To avoid any misleading information and since moisture in product is considered as an impurity, we have decided to remove the term 'Hydrate' from product name and 'xH2O' from the molecular formula for such products.
Please use it at ease since there is no difference in product quality, even if you see the previous indications on a part of label.
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| Product Number | N0986 |
Purity / Analysis Method 
|
>97.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__3__2H__4__5N__3O__4S·CH__4O__3S = 663.89 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Hygroscopic,Heat Sensitive |
| Packaging and Container
|
100MG-Glass Bottle with Plastic Insert (View image), 25MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 159989-65-8 |
| Related CAS RN
|
159989-64-7 |
| Reaxys Registry Number | 7407090 |
| PubChem Substance ID | 354333524 |
| Merck Index (14) | 6443 |
| MDL Number | MFCD00931436 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Specific rotation [a]20/D | -111 to -116 deg(C=1, MeOH)(calcd.on anh.substance) |
| Water | 2.0 to 8.0 % |
Properties (reference)
| Specific Rotation | -112° (C=1,MeOH) |
GHS
| Hazard Statements | H413 : May cause long lasting harmful effects to aquatic life. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. |
Related Laws:
| RTECS# | NW6995333 |
Transport Information:
| HS Number | 2933499090 |
Application
ヒト免疫不全ウイルス (HIV) プロテアーゼ阻害剤，ネルフィナビルメシル酸塩
Nelfinavir mesylate (AG1343) is a selective inhibitor of the human immunodeficiency virus (HIV) protease which is the enzyme responsible for post-translational processing of HIV propeptides. Inhibition of the viral protease prevents cleavage of the gag and gag-pol polyprotein resulting in the production of immature, non-infectious virus. Nelfinavir in combination with nucleoside reverse transcriptase inhibitors (NRTIs), nucleotide reverse transcriptase inhibitors (NtRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs) and/or other protease inhibitors profoundly suppresses HIV replication, and helps to increase the number of white blood cells called CD4 (T) cells which help fight off other infections. (The product is for research purpose only.)
Related compounds (NRTIs): Zidovudine [A2052], Lamivudine [L0217], Zalcitabine [D3581], Stavudine [D3580], Didanosine [D3066], Abacavir [A2694], Emtricitabine [E1007]; (NtRTIs): Tenofovir [T3006]; (NNRTIs): Efavirenz [E0997], Nevirapine [N0922].
Related compounds (NRTIs): Zidovudine [A2052], Lamivudine [L0217], Zalcitabine [D3581], Stavudine [D3580], Didanosine [D3066], Abacavir [A2694], Emtricitabine [E1007]; (NtRTIs): Tenofovir [T3006]; (NNRTIs): Efavirenz [E0997], Nevirapine [N0922].
References
- Antiviral and resistance studies of AG1343, an orally bioavailable inhibitor of human immunodeficiency virus protease.
- Activities of the human immunodeficiency virus type 1 (HIV-1) protease inhibitor nelfinavir mesylate in combination with reverse transcriptase and protease inhibitors against acute HIV-1 infection in vitro
- Viracept (Nelfinavir Mesylate, AG1343): A Potent, Orally Bioavailable Inhibitor of HIV-1 Protease
- Genotypic and Phenotypic Characterization of Human Immunodeficiency Virus Type 1 Variants Isolated from Patients Treated with the Protease Inhibitor Nelfinavir
- Anti-HIV drugs: 25 compounds approved within 25 years after the discovery of HIV (a review)
- Intracellular measurements of anti-HIV drugs indinavir, amprenavir, saquinavir, ritonavir, nelfinavir, lopinavir, atazanavir, efavirenz and nevirapine in peripheral blood mononuclear cells by liquid chromatography coupled to tandem mass spectrometry
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