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CAS RN: 133550-30-8 | Product Number: T2962
Tyrphostin AG 490

Purity: >98.0%(T)(HPLC)
- (E)-N-Benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide
Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
---|---|---|---|---|---|
20MG |
$38.00
|
1 | 1 | 4 |
|
1G |
$652.00
|
Contact Us | Contact Us | 1 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
Product Number | T2962 |
Purity / Analysis Method | >98.0%(T)(HPLC) |
Molecular Formula / Molecular Weight | C__1__7H__1__4N__2O__3 = 294.31 |
Physical State (20 deg.C) | Solid |
Storage Temperature | Frozen (<0°C) |
Store Under Inert Gas | Store under inert gas |
Condition to Avoid | Light Sensitive,Air Sensitive,Heat Sensitive |
CAS RN | 133550-30-8 |
Reaxys Registry Number | 4323263 |
PubChem Substance ID | 253661829 |
MDL Number | MFCD00236452 |
Appearance | White to Light yellow powder to crystal |
Purity(HPLC) | min. 98.0 area% |
Purity(Neutralization titration) | min. 98.0 % |
NMR | confirm to structure |
Melting Point | 215 °C |
Pictogram |
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Signal Word | Danger |
Hazard Statements | H301 : Toxic if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P302 + P352 : IF ON SKIN: Wash with plenty of soap and water. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P362 : Take off contaminated clothing and wash before reuse. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
RTECS# | UC6316197 |
UN Number (DOT-AIR) | UN3439 |
Class (DOT-AIR) | 6.1 |
Packing Group (TCI-A) | III |
HS Number | 2926.90.4801 |
References
- 1)The Janus kinases (Jaks)
- 2)Janus kinases: Components of multiple signaling pathways
- 3)Tyrphostines. 2. Heterocyclic and α-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases
- 4)Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor
- 5)JAK3, STAT, and MAPK signaling pathways as novel molecular targets for the tyrphostin AG-490 regulation of IL-2-mediated T cell response
- 6)Tyrphostin AG-490 inhibits cytokine-mediated JAK3/STAT5a/b of signal transduction and cellular proliferation of antigen-activated human T cells
- 7)JAK2 tyrosine kinase inhibitor tyrphostin AG490 downregulates the mitogen-activated protein kinase (MAPK) and signal transducer and activator of transcription (STAT) pathways and induces apoptosis in myeloma cells
Documents
Safety Data Sheet (SDS)
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Specifications
C of A & Other Certificates
Sample C of A
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Analytical Charts
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