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CAS RN: 181695-72-7 | 产品编码: V0133
Valdecoxib
×
| 产品编码 | V0133 |
纯度/分析方法 
|
>98.0%(HPLC)(N) |
| 分子式/分子量 | C__1__6H__1__4N__2O__3S = 314.36 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
冷藏 (0-10°C) |
| 应避免的情况 | 加热 |
| 包装和容器
|
1G-Glass Bottle with Plastic Insert （查看图片）, 200MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 181695-72-7 |
| Reaxys-RN | 8563786 |
| Merck Index (14) | 9900 |
| MDL编号 | MFCD00950568 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Melting point | 169.0 to 173.0 °C |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 170 °C |
| 最大吸收波长 | 202 nm (H__2O) |
| 水溶性 | 不溶 |
| 溶解性（可溶于） | 乙醇, 甲醇 |
GHS
| 象形图 |
|
| 信号词 | Warning |
| 危险性说明 | H361 : Suspected of damaging fertility or the unborn child. H373 : May cause damage to organs through prolonged or repeated exposure. H411 : Toxic to aquatic life with long lasting effects. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P391 : Collect spillage. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
相关法规
| RTECS# | DB2944030 |
运输信息
| UN编号 | UN3077 |
| 类别 | 9 |
| 包装类别 | III |
| HS编码* | 2935.90-000 |
应用
Valdecoxib: A Selective Cyclo-Oxygenase-2 (COX-2) Inhibitor
Valdecoxib (SC 65872), a non-steroidal anti-inflammatory drug (NSAID), is a selective cyclo-oxygenase-2 (COX-2) inhibitor. In theory, a drug such as valdecoxib that selectively inhibited COX-2 might block inflammation, pain, and fever produced by prostaglandins while reducing the side effects (gastric erosions and ulcers) associated with inhibition of COX-1.
References
- 1. 4-[5-Methyl-3-phenylisoxazol-4-yl]- benzenesulfonamide, Valdecoxib: A Potent and Selective Inhibitor of COX-2
- Valdecoxib: assessment of cyclooxygenase-2 potency and selectivity
- Selective cyclooxygenase-2 inhibitors: similarities and differences (a review)
- Progress in COX-2 inhibitors: a journey so far (a review)
- Pharmacokinetics and metabolism of a COX-2 inhibitor, valdecoxib, in mice
- Determination of valdecoxib and its metabolites in human urine by automated solid-phase extraction-liquid chromatography-tandem mass spectrometry
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