Главная страница > Продукция > Bench-stable Crystalline Fluoroalkylating Agents: S-(Fluoroalkyl)sulfonium Salts
Sulfonium salts are useful reagents for fluoroalkylation. For example, the trifluoromethylating agent (Umemoto's Reagent II) [D5335] affords trifluoromethylated products from various substrates.1,2) The difluoromethylating agent [D5630] is suitable for metal-free photoredox-catalyzed difluorometylation.3) In addition, these reagents are bench-stable and easily handleable solid reagents.
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The sulfonium-type trifluoromethylating agent (Umemoto's Reagent) [D5335] generates a trifluoromethyl radical (·CF3) without a photo-catalyst under light irradiation, and the resultant ·CF3 readily trifluoromethylates various aromatic compounds.2)
Trifluoromethylation by D5335
The Sulfonium-type difluoromethylating agent [D5630] also generates in-situ a difluoromethyl radical (·CHF2) in the presence of a photo-cataylst (perylene) under blue LED irradiation. The radical species reacts with various alkenes to afford difluoromehylated products.3)
Difluoromethylation by D5630
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- 1)Powerful, Thermally Stable, One-Pot-Preparable, and Recyclable Electrophilic Trifluoromethylating Agents: 2,8-Difluoro- and 2,3,7,8-Tetrafluoro-S-(trifluoromethyl)dibenzothiophenium Salts
- 2)Simple Photo-Induced Trifluoromethylation of Aromatic Rings
- 3)Metal-free Di- and Tri-fluoromethylation of Alkenes Realized by Visible-light-induced Perylene Photoredox Catalysis