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| TCI Chemistry News May 2021 | ||||
| TCI offers an extensive catalog of 30,000 high quality organic reagents suitable for benchtop-to-bulk chemistry. This issue covers our chemistry expertise in hypervalent iodine reagent for the introduction of indoles, Buchwald-Hartwig amination of aryl chlorides using a palladium catalyst and XPhos ligand, (IMes)-copper complex for methylenation and Grignard reactions, and aldol reaction. | ||||
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Hypervalent Iodine Reagent for Introduction of Indoles via C-H Activation of ArenesN-H-indole BX [I1126] is a stable hypervalent iodine compound used for the introduction of an indole ring via C-H bond activation of (hetero)arenes. In the presence of a rhodium or ruthenium catalyst, N-H-indole BX can be used to regioselectively introduce an indole ring into arenes with directing groups. In this reaction, the indole ring can be introduced in a manner that is hard to achieve by conventional methods due to the natural nucleophilicity of indole ring. Furthermore, the indole ring can be introduced at the 6- and 8-position of pyridinones and quinoline-N-oxides, respectively. | ||||
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Buchwald-Hartwig Amination of Aryl Chlorides using a Palladium Catalyst and XPhos LigandWe are proud to present the Buchwald-Hartwig cross-coupling of aryl chloride utilizing Pd(dba)2 [B1374] catalyst, and XPhos [D5038] ligand. The reaction report is performed by TCI synthesis experts. You can see not only the reaction procedure but also the useful comment and analysis data from our experts. | ||||
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(IMes)-Copper Complex for Methylenation and Grignard ReactionsChloro(1,3-dimesitylimidazol-2-ylidene)copper(I) [C2422] is an effective catalyst for the methylenation of a variety of aliphatic and aromatic aldehydes and ketones with trimethylsilyldiazomethane and triphenylphosphine. The methylenation reaction is applied to a one-pot methylenation-Diels–Alder cyclization, and a one-pot methylenation-intramolecular Heck reaction. C2422 also catalyzes the allylic substitution reactions with Grignard reagents. | ||||
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Aldol ReactionThe aldol reaction is an addition reaction of a ketone or an aldehyde with a hydrogen atom at the α-position and another ketone or aldehyde to give a β-hydroxy carbonyl compound. In this reaction, an enol or an enolate, generated by the treatment of the carbonyl compound with an acid or a base, nucleophilically adds to the other carbonyl compound to give the corresponding target compound. | ||||
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