TCI offers an extensive catalog of over 30,000 high quality organic reagents suitable for benchtop-to-bulk chemistry. This issue covers our chemistry topics as follows:

• Precious Metal Catalysts on Activated Carbon for Heterogeneous Selective Hydrogenation
• Divinyl Sulfone, a Useful Cross-linking Agent
• Amidine-based Ligands for Cross-coupling Reactions of Aryl Bromides and Redox-active Esters
• The Synthesis of Rubicene through the Scholl Reaction
• TCIMAIL 198

Precious Metal Catalysts on Activated Carbon for Heterogeneous Selective Hydrogenation

It is reported that heterogeneous precious metal catalysts show different reactivities depending on both the pore size of the immobilized phase and manufacturing method. We have 14 product lineup Palladium 5% on Carbon, PH type [P3302], Platinum 3% on Carbon (Modified by Sulfur) [P3305], or Ruthenium 5% on Carbon, SD type [R0322]. Our catalysts are characterized by finely tuned acidity or basicity, dispersity and ease filtration property. The advantages of the catalysts will improve screening experiments and process development.

Divinyl Sulfone, a Useful Cross-linking Agent

Divinyl Sulfone [D0959] is a useful reagent for intermolecular bond formation because it has two electron-deficient vinyl groups. We have abundant experience in manufacturing divinyl sulfone and can supply it in large quantities. Examples of applications include activation of agarose gels for enzyme and protein fixation, cross-linking of hyaluronic acid, and cross-linking of the conductive polymer PEDOT:PSS, and it is also attracting attention as a battery additive.

Amidine-based Ligands for Cross-coupling Reactions of Aryl Bromides and Redox-active Esters

The introduction of alkyl groups onto aromatic rings has become increasingly important in recent years for drug discovery research and the development of functional compounds. Especially, organometallic reagent-free reactions and the extension of the scope to strained cyclic alkyls are of increasing interest, and reactions using alkyl halides and carboxylic acids as coupling partners have been vigorously developed. 5-Methoxypicolinimidamide Hydrochloride [M3794] is an electron-rich amidine ligand with a methoxy group and can be used in cross-couplings between aryl bromides and redox active esters.

The Synthesis of Rubicene through the Scholl Reaction

We are proud to present the synthesis of rubicene from 9,10-diphenylanthracene using DDQ [D1070] and Trifluoromethanesulfonic Acid (=TfOH) [T0751].

Printed Magazine: TCIMAIL 198

Released in April 2024, TCI's latest issue features Ph.D. Teruo Umemoto’s article “Development of Easy-to-handle and Useful Fluorine-introducing Reagents” and Emeritus Prof. Hideo Togo's chemistry chat “Reductive Character of Hydroiodic Acid”.

We also feature research on:

Chlorinating and Brominating Reagents Suitable for Medicinal Chemistry

Ammonium Salt Suitable for Passivation of p-i-n Perovskite Solar Cells

Fluorescent Probe ADHP to Detect Hydrogen Peroxide

Modulators of the JNK Signaling Pathway

Globo-series Oligosaccharides: Gb₃ Ceramide

Keratanase II, Hydrolytic Enzyme Acting Specifically on Keratan Sulfate

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