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CAS RN: 796-42-9 | Product Number: A3339
AS-8351
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Purity: >98.0%(T)(HPLC)
Synonyms:
- N'-[(2-Hydroxynaphthalen-1-yl)methylene]isonicotinohydrazide
- N'-[(2-Hydroxy-1-naphthyl)methylene]isonicotinohydrazide
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 10MG |
$110.00
|
Contact Us | Contact Us | 25 |
|
| 50MG |
$331.00
|
Contact Us | Contact Us | 29 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | A3339 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__7H__1__3N__3O__2 = 291.31 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Hygroscopic,Heat Sensitive |
| CAS RN | 796-42-9 |
| Reaxys Registry Number | 267907 |
| PubChem Substance ID | 468590241 |
| MDL Number | MFCD00033110 |
Specifications
| Appearance | White to Orange to Green powder to crystaline |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 266 °C |
| Maximum Absorption Wavelength | 367 nm (MeOH) |
GHS
Related Laws:
Transport Information:
| HS Number | 2933.39.9200 |
Application
AS-8351: An Iron Chelator Inhibiting the Activity of Histone Demethylase
AS-8351 is reported to be an iron chelator with anti-tumor activity,1,2) and a histone demethylase inhibitor targeting KDM5B (JARID1B).3) (The product is for research purpose only.)
References
- 1) The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents II: the mechanism of action of ligands derived from salicylaldehyde benzoyl hydrazone and 2-hydroxy-1-naphthylaldehyde benzoyl hydrazone
- 2) The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents III: the effect of the ligands on molecular targets involved in proliferation
- 3) Conversion of human fibroblasts into functional cardiomyocytes by small molecules
Product Documents (Note: Some products will not have analytical charts available.)
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Specifications
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