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CAS RN: 117048-59-6 | Product Number: C2520
Combretastatin A4
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Purity: >98.0%(HPLC)
Synonyms:
- (Z)-2-Methoxy-5-(3,4,5-trimethoxystyryl)phenol
- 3'-Hydroxy-3,4,4',5-tetramethoxy-cis-stilbene
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 250MG |
$731.00
|
Contact Us | Contact Us | 5 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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| Product Number | C2520 |
Purity / Analysis Method 
|
>98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__8H__2__0O__5 = 316.35 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (<0°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Light Sensitive,Air Sensitive,Heat Sensitive |
| CAS RN | 117048-59-6 |
| Reaxys Registry Number | 4786976 |
| PubChem Substance ID | 253660156 |
| Merck Index (14) | 2494 |
| MDL Number | MFCD03453309 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 83 °C |
GHS
Related Laws:
Transport Information:
| HS Number | 2907.29.9000 |
Application
Combretastatin A4: Antimitotic Agent
Combretastatin A4 (CA-4), isolated from the African bush willow (Combretum caffrum), binds to tubulin dimers and prevents microtubule polymerization, resulting in mitotic arrest and apoptosis in endothelial cells. Concequentry, CA-4 shows strong cytotoxicity against a variety of tumor cells. Recently, various CA-4 analogs have been synthesized and evaluated for antitumor activity.
References
- Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4
- Combretastatin A-4, an agent that displays potent and selective toxicity toward tumor vasculature
- G. G. Dark, S. A. Hill, V. E. Prise, G. M. Tozer, G. R. Pettit, D. J. Chaplin, Cancer Res. 1997, 57, 1829.
- Combretastatin A-4 phosphate as a tumor vascular-targeting agent: early effects in tumors and normal tissues
- G. M. Tozer, V. E. Prise, J. Wilson, R. J. Locke, B. Vojnovic, M. R. L. Stratford, M. F. Dennis, D. J. Chaplin, Cancer Res. 1999, 59, 1626.
- Medicinal chemistry of combretastatin A4: Present and future directions
- Combretastatin A-4 analogs as anticancer agents
PubMed Literature
Documents
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Specifications
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