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CAS RN: 434937-12-9 | Product Number: C2421
1-(Cyanomethyl)piperidinium Tetrafluoroborate
Purity: >98.0%(N)
Synonyms:
Product Documents:
Size | Unit Price | Belgium | Japan* | Quantity |
---|---|---|---|---|
5G |
€77.00
|
1 | 8 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
Product Number | C2421 |
Purity / Analysis Method | >98.0%(N) |
Molecular Formula / Molecular Weight | C__7H__1__3BF__4N__2 = 212.00 |
Physical State (20 deg.C) | Solid |
Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
Store Under Inert Gas | Store under inert gas |
Condition to Avoid | Moisture Sensitive |
CAS RN | 434937-12-9 |
Reaxys Registry Number | 9533187 |
PubChem Substance ID | 125307530 |
Specifications
Appearance | White to Almost white powder to crystal |
Purity(with Total Nitrogen) | min. 98.0 % |
Melting point | 103.0 to 107.0 °C |
NMR | confirm to structure |
Properties (reference)
Melting Point | 105 °C |
GHS
Pictogram | |
Signal Word | Danger |
Hazard Statements | H302 + H312 + H332 : Harmful if swallowed, in contact with skin or if inhaled. H314 : Causes severe skin burns and eye damage. |
Precautionary Statements | P260 : Do not breathe dust. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P303 + P361 + P353 : IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water. P301 + P330 + P331 : IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor. P305 + P351 + P338 + P310 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor. |
Related Laws:
Transport Information:
UN Number | UN1759 |
Class | 8 |
Packing Group | III |
HS Number | 2933399990 |
Application
A Useful Condensation Activator Bearing Less Nucleophilicity and No Deliquescence
Wada et al. developed 1-(cyanomethyl)piperidinium tetrafluoroborate (1) conjugates, with a highly less nucleophilic counteranion, BF4-.1) It has appropriate proton-donating ability as a condensation activator to give the corresponding dinucleotide without any loss of the diastereopurity. In addition, the activator has no deliquescence and good solubility in CH3CN. Therefore, the activator can be broadly applicable to condensation reactions.
References
- 1)Synthesis of oligonucleoside phosphorothioates via the condensation reactions using 1-(cyanomethyl)piperidinium tetrafluoroborate
- a)N. Oka, T. Wada, K. Saigo, J. Am. Chem. Soc. 2002, 124, 4962.
- b)N. Oka, T. Wada, K. Saigo, J. Am. Chem. Soc. 2003, 125, 8307.
- c)S. Fujiwara, N. Iwamoto, K. Saigo, T. Sato, T. Wada, PCT Int. Appl. WO 2005092909.
PubMed Literature
Articles/Brochures
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[TCIMAIL No.150] A Useful Condensation Activator Bearing Less Nucleophilicity and No DeliquescenceProduct Documents (Note: Some products will not have analytical charts available.)
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