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CAS RN: 50978-45-5 | Product Number: F0854


Purity: >98.0%(GC)
≥20  ≥20 
18   ≥20 
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Product Number F0854
Purity / Analysis Method >98.0%(GC)
Molecular Formula / Molecular Weight C__8H__5NO__4S = 211.19  
Physical State (20 deg.C) Solid
Store Under Inert Gas Store under inert gas
Condition to Avoid Moisture Sensitive
CAS RN 50978-45-5
Reaxys Registry Number 21741916
PubChem Substance ID 160871419
Appearance White to Almost white powder to crystal
Purity(GC) min. 98.0 %
Properties (reference)
Solubility (slightly sol. in) Dimethylformamide
Related Laws: / Compliance with laws, Regulations
Transport Information:
Easily Accessible and Highly Reactive Crystalline CO Surrogate, N-formylsaccharin


Typical Procedure (entry 1):
Pd(OAc)2 (10.1 mg, 0.045 mmol, 3.0 mol%), DPPB (28.8 mg, 0.068 mmol, 4.5 mol%), N-formylsaccharin (475 mg, 2.25 mmol, 1.5eq.), and Na2CO3 (238 mg, 2.25 mmol, 1.5eq.) are added to a 30 mL test tube, which is then evacuated and backfilled three times with N2. A solution of bromobenzene (158 µL, 1.50 mmol) and Et3SiH (311 µL, 1.95 mmol, 1.3eq.) in DMF (6 mL) is added to the test tube under N2. The tube is immediately sealed and the mixture is stirred efficiently for 10 min at rt. The mixture is subsequently warmed to 75 °C and stirred for a further 16 h. The reaction mixture is cooled to rt, then diluted with Et2O (15 mL), and washed with H2O (15 mL). The aqueous layer is extracted two times with Et2O (15 mL). The combined organic layer is dried over MgSO4, filtered, and concentrated. The obtained residue is purified by flash column chromatography on silica gel (eluent: 3–5% Et2O in n-pentane) to provide benzaldehyde as a colorless oil (132 mg, 83%).


Novel Powerful Formylating Reagent


1)N-Formylsaccharin: A new formylating agent

T. Cochet, V. Bellosta, A. Greiner, D. Roche, J. Cossy, Synlett 2011, 1920.

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