text.skipToContent text.skipToNavigation

Maximum quantity allowed is 999

Please select the quantity

CAS RN: 50978-45-5 | Product Number: F0854

N-Formylsaccharin


Purity: >98.0%(GC)
Synonyms:
Documents:
5G
A$150.00
≥20  ≥20 
25G
A$548.00
18   ≥20 
* Please contact our distributor of Chem-Supply if you would like to purchase TCI products. The above prices do not include freight cost, customs charge and other charges to the destination.
* Chem-Supply Pty Ltd (Phone: 8-8440-2000 / email:  info@chemsupply.com.au)

Product Number F0854
Purity / Analysis Method >98.0%(GC)
Molecular Formula / Molecular Weight C__8H__5NO__4S = 211.19  
Physical State (20 deg.C) Solid
Store Under Inert Gas Store under inert gas
Condition to Avoid Moisture Sensitive
CAS RN 50978-45-5
Reaxys Registry Number 21741916
PubChem Substance ID 160871419
Specifications
Appearance White to Almost white powder to crystal
Purity(GC) min. 98.0 %
Properties (reference)
Solubility (slightly sol. in) Dimethylformamide
GHS
Related Laws: / Compliance with laws, Regulations
Transport Information:
Application
Easily Accessible and Highly Reactive Crystalline CO Surrogate, N-formylsaccharin

F0854

Typical Procedure (entry 1):
Pd(OAc)2 (10.1 mg, 0.045 mmol, 3.0 mol%), DPPB (28.8 mg, 0.068 mmol, 4.5 mol%), N-formylsaccharin (475 mg, 2.25 mmol, 1.5eq.), and Na2CO3 (238 mg, 2.25 mmol, 1.5eq.) are added to a 30 mL test tube, which is then evacuated and backfilled three times with N2. A solution of bromobenzene (158 µL, 1.50 mmol) and Et3SiH (311 µL, 1.95 mmol, 1.3eq.) in DMF (6 mL) is added to the test tube under N2. The tube is immediately sealed and the mixture is stirred efficiently for 10 min at rt. The mixture is subsequently warmed to 75 °C and stirred for a further 16 h. The reaction mixture is cooled to rt, then diluted with Et2O (15 mL), and washed with H2O (15 mL). The aqueous layer is extracted two times with Et2O (15 mL). The combined organic layer is dried over MgSO4, filtered, and concentrated. The obtained residue is purified by flash column chromatography on silica gel (eluent: 3–5% Et2O in n-pentane) to provide benzaldehyde as a colorless oil (132 mg, 83%).

References


Application
Novel Powerful Formylating Reagent

References

1)N-Formylsaccharin: A new formylating agent

T. Cochet, V. Bellosta, A. Greiner, D. Roche, J. Cossy, Synlett 2011, 1920.


PubMed Literature


Documents
Safety Data Sheet (SDS) Search
Please select Language.

The requested SDS is not available.

• Please check that the Product Number you have entered is correct.

• If your information is correct and you are still not able to view the requested SDS,  please Contact Us for more information.

C of A & Other Certificates
Please enter Lot Number Incorrect Lot Number is entered
Other Documents