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CAS RN: 555-30-6 | Product Number: D1817

3-(3,4-Dihydroxyphenyl)-2-methyl-L-alanine Sesquihydrate

Purity: >98.0%(T)(HPLC)
  • α-Methyl-L-DOPA Sesquihydrate
  • Methyldopa Sesquihydrate
2   ≥20 
2   14  

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Product Number D1817
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__1__0H__1__3NO__4·1^^1/__2H__2O = 238.24  
Physical State (20 deg.C) Solid
Store Under Inert Gas Store under inert gas
Condition to Avoid Light Sensitive,Air Sensitive
CAS RN 555-30-6
Related CAS RN 41372-08-1
Reaxys Registry Number 2807721
PubChem Substance ID 87568286
Merck Index (14) 6055
MDL Number


Properties (reference)
Specific Rotation -14° (C=1,H2O)
Related Laws: / Compliance with laws, Regulations
Enzyme Commission 209-089-2
RTECS# AY5950000
Transport Information:
HS Number 2922500090
Methyldopa: An Aromatic-Amino Acid Decarboxylase Inhibitor

Methyldopa is an aromatic-amino acid decarboxylase inhibitor. It inhibits the decarboxylation of L-DOPA [D0600], thereby interfering with the formation of dopamine [A0305 (HCl salt)], a precursor of L-norepinephrine [A0906 (bitartrate)]. Methyldopa is an effective anti-hypertensive agent that reduces both supine and standing blood pressure. At first, the anti-hypertensive activity was believed to be related with the inhibition. Nowadays, methyldopa is metabolized to α-methylnorepinephrine and this compound is thought to stimulate central nerve α-adrenergic receptors, producing a decrease in peripheral sympathetic outflow, and resulting in decreasing blood pressure. (The product is for research purpose only.)


PubMed Literature

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