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CAS RN: 50924-49-7 | Product Number: M2399

Mizoribine


Purity: >98.0%(HPLC)
Synonyms:
  • 1-(β-D-Ribofuranosyl)-5-hydroxyimidazole-4-carboxamide
Documents:
50MG
€87.00
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250MG
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Product Number M2399
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__9H__1__3N__3O__6 = 259.22  
Physical State (20 deg.C) Solid
Storage Temperature 0-10°C
Condition to Avoid Heat Sensitive
CAS RN 50924-49-7
Reaxys Registry Number 8155135
PubChem Substance ID 253659680
Merck Index (14) 6222
MDL Number

MFCD00057221

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Elemental analysis(Nitrogen) 15.50 to 16.70 %
Specific rotation [a]20/D -25.0 to -27.0 deg(C=2,H2O)
Properties (reference)
Melting Point 198 °C(dec.)
Specific Rotation -26° (C=2,H2O)
Maximum Absorption Wavelength 280 nm
GHS
Pictogram Pictogram Pictogram
Signal Word Danger
Hazard Statements H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
H360 : May damage fertility or the unborn child.
H340 : May cause genetic defects.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P201 : Obtain special instructions before use.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P308 + P313 : IF exposed or concerned: Get medical advice/ attention.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
Related Laws: / Compliance with laws, Regulations
RTECS# NI3980000
Transport Information:
HS Number 2940000080
Application
Studies on Immune System
References

Mizoribine and mycophenolate mofetil

H. Ishikawa, Curr. Med. Chem. 1999, 6, 575.

Studies on bredinin. I. Isolation, characterization, and biological properties

K. Mizuno, M. Tsujino, M. Takada, M. Hayashi, K. Atsumi, K. Asano, T. Matsuda, J. Antibiot. 1974, 27, 775.

Guanine ribonucleotide depletion inhibits T cell activation. Mechanism of action of the immunosuppressive drug

L. A. Turka, J. Dayton, G. Sinclair, C. B. Thompson, B. S. Mitchell, J. Clin. Invest. 1991, 87, 940.

Comparison of the effects of mizoribine with those of azathioprine, 6-mercaptopurine, and mycophenolic acid on T

J. S. Dayton, L. A. Turka, C. B. Thompson, B. S. Mitchell, Mol. Pharmacol. 1992, 41, 671.


Application
Studies on Antivirus Activity of Mizoribine
References

Mizoribine inhibits hepatitis C virus RNA replication: Effect of combination with interferon-α

K. Naka, M. Ikeda, K.-i. Abe, H. Dansako, N. Kato, Biochem. Biophys. Res. Commun. 2005, 330, 871.

Inhibition of bovine viral diarrhea virus (BVDV) by mizoribine: synergistic effect of combination with interferon-α

K. Yanagida, C. Baba, M. Baba, Antiviral Res. 2004, 64, 195.

Inhibitory effect of mizoribine and ribavirin on the replication of severe acute respiratory syndrome (SARS)-associated coronavirus

M. Saijo, S. Morikawa, S. Fukushi, T. Mizutani, H. Hasegawa, N. Nagata, N. Iwata, I. Kurane, Antiviral Res. 2005, 66, 159.

Antiviral activities of mizoribine and other inosine monophosphate dehydrogenase inhibitors against several ortho-

Y. Kosugi, Y. Saito, S. Mori, J. Watanabe, M. Baba, S. Shigeta, Antiviral Chem. Chemother. 1994, 5, 366.


PubMed Literature


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