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CAS RN: 120511-73-1 | Product Number: A2370
Anastrozole
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Purity: >98.0%(T)(HPLC)
Synonyms:
- α,α,α',α'-Tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-benzenediacetonitrile
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 100MG |
$93.00
|
1 | 2 | ≥60 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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| Product Number | A2370 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__7H__1__9N__5 = 293.37 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container
|
100MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 120511-73-1 |
| Reaxys Registry Number | 8005958 |
| PubChem Substance ID | 135727309 |
| MDL Number | MFCD00866298 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 82.0 to 86.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 84 °C |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | CZ1465000 |
Transport Information:
| UN Number (DOT-AIR) | UN3439 |
| Class (DOT-AIR) | 6.1 |
| Packing Group (TCI-A) | III |
| HS Number | 2934.99.4400 |
Application
Anastrozole: A Potent and Selective Aromatase Inhibitor
Anastrozole is a third generation, and a potent and selective aromatase inhibitor. Aromatase is responsible enzyme for the aromatization of androgens into estrogens in the periphery. Anastrozole inhibits aromatase and estrogen synthesis, resulting in suppressing tumor growth. Anastrozole alone or a combination agent with tamoxifen citrate [T2510] is used for the treatment for postmenopausal women with breast cancer. (The product is for research purpose only.)
References
- Influence of anastrozole (Arimidex), a selective, non-steroidal aromatase inhibitor, on in vivo aromatization and plasma estrogen levels in postmenopausal women with breast cancer
- The preclinical pharmacology of "Arimidex" (anastrozole; ZD1033) - a potent, selective aromatase inhibitor
- Inhibition of human drug metabolizing cytochromes P450 by anastrozole, a potent and selective inhibitor of aromatase
- Aromatase inhibitors in the treatment of breast cancer (a review)
- Development and validation of a simple and sensitive high performance liquid chromatographic method for the simultaneous determination of anastrozole, bicalutamide, tamoxifen, and their synthetic impurities
PubMed Literature
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Specifications
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