text.skipToContent text.skipToNavigation

Maximum quantity allowed is 999

Please select the quantity

CAS RN: 163927-31-9 | Product Number: A5568

(R)-(-)-DBD-Py-NCS [=(R)-(-)-4-(N,N-Dimethylaminosulfonyl)-7-(3-isothiocyanatopyrrolidin-1-yl)-2,1,3-benzoxadiazole] [for HPLC Labeling]


Purity: >98.0%(HPLC)
Synonyms:
  • (R)-(-)-4-(N,N-Dimethylaminosulfonyl)-7-(3-isothiocyanatopyrrolidin-1-yl)benzofurazan
  • (R)-(-)-4-(N,N-Dimethylaminosulfonyl)-7-(3-isothiocyanatopyrrolidin-1-yl)-2,1,3-benzoxadiazole
Product Documents:
100MG
$378.00
1   1   1  

* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
* To send your quote request for bulk quantities, please click on the "Request Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.


Product Number A5568
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__1__3H__1__5N__5O__3S__2 = 353.42 
Physical State (20 deg.C) Solid
Storage Temperature Refrigerated (0-10°C)
Store Under Inert Gas Store under inert gas
Condition to Avoid Air Sensitive,Heat Sensitive
Packaging and Container 100MG-Glass Bottle with Plastic Insert (View image)
CAS RN 163927-31-9
PubChem Substance ID 87563185
MDL Number

MFCD00671493

Specifications
Appearance Light yellow to Brown powder to crystal
Purity(HPLC) min. 98.0 area%
Optical purity(LC) min. 99.0 ee%
Melting point 157.0 to 161.0 °C
Effect test of HPLC derivatization Effective as labeling agent for DL-1-Phenylethylamine
NMR confirm to structure
Properties (reference)
Specific Rotation -285° (C=0.4,CH3CN)
GHS
Related Laws:
Transport Information:
HS Number 2935.90.9500
Application
HPLC Labeling Reagent for Chiral Amines and Thiols

The compound 1 is an HPLC fluorescence labeling reagent for optical purity determination. This compound easily reacts with amino or mercapto groups, which are directly linked to the asymmetric carbon atom and produces diastereomers of thiourea or dithiocarbamate. These diasteromers can be separated by reversed phase HPLC, and an excellent chromatogram can be obtained by fluorescence detection at the excitation and emission wavelengths of 460 nm and 550 nm, respectively. [The detection limit: thiopronine = 0.5 pmol (S/N = 2)]
Since both (R)- and (S)-isomers of the derivatization reagents are commercially available on the market, it is possible to change an elution order of the derivatized diastereomers by selecting either enantiomer of the derivatization reagent. Thus, an enantiomer of the aminocompound, whose existing quantity is very small, can be eluted out first and quantified with a high precision. Moreover, there are reports for the application of these isomers to Edman Degradation.

Application example:
Add 10 µL of 5 mM HPLC labeling reagent 1 / acetonitrile solution in 10 µL of 1 mM amine / acetonitrile-H2O (1:1) solution (containing 2% triethylamine) to a vessel, close the cap of the reaction vessel and incubate the mixture at 55 °C for 10 min. Then, add 480 µL of a mixture solution of 1 M acetic acid and acetonitrile-H2O (1:1) solution, and dilute this reactant mixture 10x by acetonitrile. Use 5 µL of this diluted solution as an HPLC sample solution.

References


PubMed Literature


Articles/Brochures

TCIMAIL
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
Please select Language.

The requested SDS is not available.

Please Contact Us for more information.

Specifications
C of A & Other Certificates
Please enter Lot Number Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.

The product with the lot number searched for has been discontinued and no related documentation is available.

Sample C of A
This is a sample C of A and may not represent a recently manufactured lot of the product.

A sample C of A for this product is not available at this time.

Analytical Charts
Please enter Lot Number Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.

The requested analytical chart is not available. Sorry for the inconvenience.

The product with the lot number searched for has been discontinued and no related documentation is available.

Other Documents

Session Status
Your session will timeout in 10 minutes. You will be redirected to the HOME page after session timeout. Please click the button to continue session from the same page. minute. You will be redirected to the HOME page after session timeout. Please click the button to continue session from the same page.

Your session has timed out. You will be redirected to the HOME page.