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CAS RN: 55-98-1 | Product Number: B1022
1,4-Butanediol Dimethanesulfonate
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Purity: >97.0%(T)
Synonyms:
- Busulfan
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|---|
| 25G |
$160.00
|
2 | 1 | ≥40 |
|
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| Product Number | B1022 |
Purity / Analysis Method 
|
>97.0%(T) |
| Molecular Formula / Molecular Weight | C__6H__1__4O__6S__2 = 246.29 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Moisture Sensitive |
| CAS RN | 55-98-1 |
| Reaxys Registry Number | 1791786 |
| PubChem Substance ID | 87563973 |
| SDBS (AIST Spectral DB) | 10191 |
| Merck Index (14) | 1505 |
| MDL Number | MFCD00007562 |
Specifications
| Appearance | White to Light yellow to Light orange powder to crystaline |
| Purity(Neutralization titration) | min. 97.0 % |
| Melting point | 114.0 to 118.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 118 °C |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 + H311 + H331 : Toxic if swallowed, in contact with skin or if inhaled. H350 : May cause cancer. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P362 : Take off contaminated clothing and wash before reuse. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water.Call a POISON CENTER/doctor if you feel unwell. P304 + P340 + P311 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. P405 : Store locked up. |
Related Laws:
| RTECS# | EK1750000 |
Transport Information:
| UN Number (DOT-AIR) | UN2811 |
| Class (DOT-AIR) | 6.1 |
| Packing Group (TCI-A) | III |
| HS Number | 2905.59.1000 |
Application
Busulfan: A Bifunctional Antitumor Alkylating Agent
Busulfan (1,4-butanediol dimethanesulfonate) is a bifunctional antitumor alkylating agent. Busulfan produces a greater degree of DNA-protein and DNA interstrand crosslinking, and thus may effectively induce DNA damage which may play an important role in the cytotoxicity. Busulfan has been used widely for the treatment of chronic myelogenous leukemia, and is currently used in the myeloablative conditioning regimen before hematopoietic stem cell transplantation. (The product is for research purpose only.)
References
- Toxicological review of busulfan (Myleran)
- Comparison of the mechanism of action of busulfan with hepsulfam, a new antileukemic agent, in the L1210 cell line
- An evidence-based analysis of the effect of busulfan, hydroxyurea, interferon, and allogeneic bone marrow transplantation in treating the chronic phase of chronic myeloid leukemia: developed for the american society of hematology (a review)
- DNA intrastrand cross-link at the 5'-GA-3' sequence formed by busulfan and its role in the cytotoxic effect
- Busulfan in hematopoietic stem cell transplantation (a review)
PubMed Literature
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Safety Data Sheet (SDS)
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Specifications
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