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CAS RN: 70872-29-6 | Product Number: I1065
Isoxanthohumol
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Purity: >96.0%(HPLC)
Synonyms:
- (S)-7-Hydroxy-2-(4-hydroxyphenyl)-5-methoxy-8-(3-methylbut-2-en-1-yl)chroman-4-one
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 10MG |
$58.00
|
1 | 1 | Contact Us |
|
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| Product Number | I1065 |
| Purity / Analysis Method | >96.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__1H__2__2O__5 = 354.40 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 70872-29-6 |
| Reaxys Registry Number | 10199264 |
| PubChem Substance ID | 354335594 |
| MDL Number | MFCD00238718 |
Specifications
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 96.0 area% |
| Melting point | 195.0 to 200.0 °C |
| Specific rotation [a]20/D | -18.0 to -23.0 deg(C=0.05, MeOH) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 197 °C |
| Specific Rotation | -20° (C=0.05,MeOH) |
| Maximum Absorption Wavelength | 325 nm |
GHS
Related Laws:
Transport Information:
| HS Number | 2932.99.6100 |
Application
Isoxanthohumol: One of the Important Prenylflavonoids Found in Hops
Isoxanthohumol (abbreviated as IXN or IX), xanthohumol (XN) [X0068] and 8-prenylnaringenin (8-PN) [CAS: 53846-50-7] are important prenylflavonoids found in hops (Humulus lupulus L.) which have been used as essential ingredient in beer, providing the typical bitterness and hoppy flavor. In 2000s, the plant has gained increasing attention as a source of prenylflavonoids. 8-PN has been identified as one of the most potent phytoestrogens, but 8-PN concentrations in hops are very low. In contrast, isoxanthohumol has limited estrogenic activity, but the concentrations in hops are very high. However, reportedly, isoxanthohumol may be O-demethylated to 8-PN by human intestinal microbiota. Futhermore, isoxanthohumol reportedly exhibits an antiproliferative activity against cancer cells. In addition, another natural source of isoxanthohumol is a shrub Sophora flavescens, used in traditional Chinese medicine. (The product is for research purpose only.)
References
- Activation of proestrogens from hops (Humulus lupulus L.) by intestinal microbiota; conversion of isoxanthohumol into 8-prenylnaringenin
- The prenylflavonoid isoxanthohumol from hops (Humulus lupulus L.) is activated into the potent phytoestrogen 8-prenylnaringenin in vitro and in the human intestine
- Isoxanthohumol - Biologically active hop flavonoid (a review)
- Quantitative analysis of xanthohumol and related prenylflavonoids in hops and beer by liquid chromatography-tandem mass spectrometry
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