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CAS RN: 68-35-9 | Product Number: S0579
Sulfadiazine
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Purity: >99.0%(T)(HPLC)
Synonyms:
- 4-Amino-N-(2-pyrimidinyl)benzenesulfonamide
- N-(2-Pyrimidinyl)sulfanilamide
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|---|
| 25G |
$36.00
|
7 | 1 | ≥60 |
|
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| Product Number | S0579 |
Purity / Analysis Method 
|
>99.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__0H__1__0N__4O__2S = 250.28 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Light Sensitive,Heat Sensitive |
| CAS RN | 68-35-9 |
| Reaxys Registry Number | 235192 |
| PubChem Substance ID | 87560164 |
| Merck Index (14) | 8903 |
| MDL Number | MFCD00006065 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 99.0 area% |
| Purity(Neutralization titration) | min. 99.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 256 °C(dec.) |
| Solubility in water | Insoluble |
| Solubility (soluble in) | Dimethylformamide |
| Solubility (slightly sol. in) | Acetone |
| Solubility (insoluble in) | Ether, Ethanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. H317 : May cause an allergic skin reaction. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P272 : Contaminated work clothing must not be allowed out of the workplace. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P302 + P352 : IF ON SKIN: Wash with plenty of soap and water. P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention. P362 : Take off contaminated clothing and wash before reuse. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| RTECS# | WP1925000 |
Transport Information:
| HS Number | 2933.59.8000 |
Application
Sulfadiazine, an inhibitor of dihydropteroate synthase
Sulfadiazine is one of the sulfonamides and has an anti-bacterial effect. It inhibits dihydropteroate synthase of bacteria, protozoa and fungi resulting in inhibition of DNA or RNA synthesis of bacteria and other microbes. It also shows anti-toxoplasma effect by using together with pyrimethamine [P2037]. The mammals including human do not have this part of folate synthetic system, so that it is considered to be non-effective for them. (The product is for research purpose only.)
References
- Chemotherapy. II. Some sulfanilamido heterocycles
- Sulfadiazine (a review)
- Toxoplasmosis (a review)
- Dihydrofolate reductase inhibitors as antibacterial agents (a review)
PubMed Literature
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Specifications
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