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CAS RN: 27314-97-2 | Product Number: T3823
Tirapazamine
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Purity: >98.0%(HPLC)
Synonyms:
- SR 259075
- 3-Aminobenzo[e][1,2,4]triazine 1,4-Dioxide
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 50MG |
$188.00
|
Contact Us | Contact Us | 28 |
|
| 250MG |
$688.00
|
1 | Contact Us | 14 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
* To send your quote request for bulk quantities, please click on the "Request Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | T3823 |
Purity / Analysis Method 
|
>98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__7H__6N__4O__2 = 178.15 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 27314-97-2 |
| Reaxys Registry Number | 179322 |
| PubChem Substance ID | 468592963 |
| Merck Index (14) | 9461 |
| MDL Number | MFCD00132954 |
Specifications
| Appearance | Orange to Red powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
Properties (reference)
| Melting Point | 230 °C(dec.) |
| Maximum Absorption Wavelength | 457 nm (H__2O) |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P302 + P352 : IF ON SKIN: Wash with plenty of soap and water. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P362 : Take off contaminated clothing and wash before reuse. |
Related Laws:
| RTECS# | DM0671500 |
Transport Information:
| HS Number | 2933.99.7500 |
Application
Tirapazamine: A Hypoxia-Activated Antitumor Agent
Tirapazamine, also known as SR-4233, is a hypoxia-activated antitumor agent.1-3) It is converted to the reactive one-electron reduction product (radical anion) under hypoxic condition. The radical product abstracts a proton from DNA to form DNA radicals, largely at C4’ on the ribose ring. Tirapazamine can also oxidized such DNA radicals to cytotoxic DNA strand breaks.4) Recently, the antitumor effects of tirapazamine in combination with cisplatin [D3371]3), and tirapazamine prodrugs5) have been studied. (The product is for research purpose only.)
References
- 1) SR-4233: a new bioreductive agent with high selective toxicity for hypoxic mammalian cells
- 2) SR 4233 (tirapazamine): a new anticancer drug exploiting hypoxia in solid tumours (a review)
- 3) The hypoxic cell: a target for selective cancer therapy-eighteenth Bruce F. Cain memorial award lecture
- 4) Selective Potentiation of the Hypoxic Cytotoxicity of Tirapazamine by Its 1-N-Oxide Metabolite SR 4317
- 5) Q6, a novel hypoxia-targeted drug, regulates hypoxia-inducible factor signaling via an autophagy-dependent mechanism in hepatocellular carcinoma
Product Documents (Note: Some products will not have analytical charts available.)
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Specifications
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