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Published TCIMAIL newest issue No.198
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CAS RN: 78110-38-0 | Product Number: A2466
Aztreonam
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Purity: >98.0%(HPLC)
Synonyms:
- 2-[[(Z)-[1-(2-Amino-4-thiazolyl)-2-[[(2S,3S)-2-methyl-4-oxo-1-sulfo-3-azetidinyl]amino]-2-oxoethylidene]amino]oxy]-2-methylpropionic Acid
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 500MG |
€32.00
|
1 | 37 |
|
| 5G |
€205.00
|
Contact Us | 12 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | A2466 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__3H__1__7N__5O__8S__2 = 435.43 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container | 500MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 78110-38-0 |
| Reaxys Registry Number | 3577211 |
| PubChem Substance ID | 160871057 |
| Merck Index (14) | 925 |
| MDL Number | MFCD00072145 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 95.0 % |
| Specific rotation [a]20/D | -26.0 to -32.0 deg(C=0.5、H2O) |
Properties (reference)
| Melting Point | 227 °C(dec.) |
| Specific Rotation | -28° (C=0.5,H2O) |
| Solubility (insoluble in) | Ethanol |
GHS
Related Laws:
| EC Number | 278-839-9 |
| RTECS# | UA2451400 |
Transport Information:
| HS Number | 2941900000 |
Application
Aztreonam: The First Monobactam Antibiotic with Resistance to beta-Lactamases
Aztreonam is the first synthetic monocyclic beta-lactam antibiotic (monobactam). It has strong activity against susceptible gram-negative bacteria, including Pseudomonas aeruginosa. It has no useful activity against gram-positive bacteria or anaerobes. It is highly resistant to hydrolytic inactivation caused by plasmid-mediated or chromosomally mediated beta-lactamases, but is inactivated by extended-spectrum beta-lactamases (ESBLs).
References
- Aztreonam. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use
- The new monobactams: chemistry and biology
- Carbapenems and monobactams: imipenem, meropenem, and aztreonam
- Cefepime-aztreonam: a unique double β-lactam combination for Pseudomonas aeruginosa
- Background and Rationale for Revised Clinical and Laboratory Standards Institute Interpretive Criteria (Breakpoints) for Enterobacteriaceae and Pseudomonas aeruginosa: I. Cephalosporins and Aztreonam
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