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CAS RN: 179324-69-7 | Product Number: B5741
Bortezomib
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Purity: >98.0%(HPLC)
Synonyms:
- (R)-3-Methyl-1-[(S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido]butylboronic Acid
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 10MG |
€58.00
|
3 | ≥100 |
|
|
| 50MG |
€193.00
|
1 | ≥40 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | B5741 |
Purity / Analysis Method 
|
>98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__9H__2__5BN__4O__4 = 384.24 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (-20°C) |
| Condition to Avoid | Light Sensitive,Heat Sensitive |
| CAS RN | 179324-69-7 |
| Reaxys Registry Number | 8723817 |
| PubChem Substance ID | 468590677 |
| Merck Index (14) | 1351 |
| MDL Number | MFCD09056737 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Specific rotation [a]20/D | -50.0 to -55.0 deg(C=1, MeOH) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 123 °C |
| Solubility in water | Soluble |
| Degree of solubility in water | 76 mg/l |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 + H311 + H331 : Toxic if swallowed, in contact with skin or if inhaled. H361 : Suspected of damaging fertility or the unborn child. |
| Precautionary Statements | P261 : Avoid breathing dust. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. |
Related Laws:
| RTECS# | ED7771666 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
| HS Number | 2933998090 |
Application
Adeno-associated virus vector transduction enhancer
Bortezomib increases transduction by adeno-associated virus (AAV) vectors.1)
References
- 1) Identification and validation of small molecules that enhance recombinant adeno-associated virus transduction following high-throughput screens
Application
Bortezomib: A Reversible Inhibitor of the 26S Proteasome in Mammalian Cells
Bortezomib (PS-341) is a reversible inhibitor of the 26S proteasome in mammalian cells. The proteasome is an abundant multi-enzyme complex that provides the main pathway for degradation of intracellular proteins in eukaryotic cells. The 26S proteasome is a large protein complex that degrades ubiquitinated proteins. The ubiquitin-proteasome pathway plays an essential role in regulating the intracellular concentration of specific proteins. The orderly degradation of cellular proteins is critical for normal cell cycling and function, and inhibition of the ubiquitin-proteasome pathway with bortezomib results in cell-cycle arrest and apoptosis. (The product is for research purpose only.)
References
- The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells
- The proteasome: a suitable antineoplastic target (a review)
- Bortezomib as the first proteasome inhibitor anticancer drug: current status and future perspectives (a review)
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