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Published TCIMAIL newest issue No.198
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CAS RN: 113558-15-9 | Product Number: B6443
Baohuoside I
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Purity: >95.0%(T)(HPLC)
Synonyms:
- Icariside II
- 3-[(6-Deoxy-α-L-mannopyranosyl)oxy]-5,7-dihydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25MG |
€271.00
|
Contact Us | 17 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | B6443 |
| Purity / Analysis Method | >95.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__7H__3__0O__1__0 = 514.53 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 113558-15-9 |
| Reaxys Registry Number | 71248 |
| MDL Number | MFCD15071140 |
Specifications
| Appearance | White to Light yellow to Green powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(Neutralization titration) | min. 95.0 % |
| Melting point | 202.0 to 206.0 °C |
| Specific rotation | -127 to -137 deg(C=1, ethanol) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 204 °C |
GHS
Related Laws:
| RTECS# | DJ2980270 |
Transport Information:
| HS Number | 2938909090 |
Application
Baohuoside I: An Anticancer Metabolite of Icariin
Herba Epimedii is one of most popular herbs used in China traditionally for the treatment of multiple diseases. Baohuoside I (a synonym: Icariside II) is a hydrolysis metabolite of icariin [I0862] which is derived from Herba Epimedii.1,2) There are reported that baohuoside I possess anticancer activities against various human cancer cell lines in vitro and mouse tumor models in vivo via their effects on multiple biological pathways including STAT3, PI3K/AKT, MAPK/ERK, COX-2/PGE2 and β-Catenin.3,4) In addition, baohuoside I exerts its antimetastatic effect through the downregulation of CXCR4 (CXC chemokine receptor type 4) expression.5) (The product is for research purpose only.)
References
- 1) LC-MS/MS method for the simultaneous determination of icariin and its major metabolites in rat plasma
- W. Xu, Y. Zhang, M. Yang, Z. Shen, X. Zhang, W. Zhang, H. Li, J. Pharm. Biomed. Anal. 2007, 45, 667.
- 2) Preparation of icariside II from icariin by enzymatic hydrolysis method
- 3) Targeting apoptosis and multiple signaling pathways with icariside II in cancer cells
- 4) The Anticancer Properties of Herba Epimedii and Its Main Bioactive Componentsicariin and Icariside II (a review)
- 5) Baohuoside I Suppresses Invasion of Cervical and Breast Cancer Cells through the Downregulation of CXCR4 Chemokine Receptor Expression
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