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Published TCIMAIL newest issue No.198
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CAS RN: 64485-93-4 | Product Number: C2224
Cefotaxime Sodium Salt
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Purity: >96.0%(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 5G |
€74.00
|
8 | ≥100 |
|
| 25G |
€238.00
|
3 | ≥100 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
Supplemental Product Information:
This product has not been tested for potency and is guaranteed for chemical purity.
| Product Number | C2224 |
| Purity / Analysis Method | >96.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__6H__1__6N__5NaO__7S__2 = 477.44 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Light Sensitive,Hygroscopic,Heat Sensitive |
| CAS RN | 64485-93-4 |
| Related CAS RN | 63527-52-6 |
| Reaxys Registry Number | 6564218 |
| PubChem Substance ID | 87560124 |
| SDBS (AIST Spectral DB) | 52166 |
| Merck Index (14) | 1933 |
| MDL Number | MFCD00079073 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 96.0 area% |
| Purity(Nonaqueous Titration) | min. 96.0 % |
| Specific rotation [a]20/D | +58.0 to +64.0 deg(C=1, H2O)(calcd.on dried substance) |
| Drying loss | max. 3.0 % |
Properties (reference)
| Melting Point | 163 °C(dec.) |
| Specific Rotation | 61° (C=1,H2O) |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H317 : May cause an allergic skin reaction. H334 : May cause allergy or asthma symptoms or breathing difficulties if inhaled. |
| Precautionary Statements | P261 : Avoid breathing dust. P280 : Wear protective gloves. P284 : Wear respiratory protection. P342 + P311 : If experiencing respiratory symptoms: Call a POISON CENTER/doctor. P304 + P340 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention. |
Related Laws:
| EC Number | 264-915-9 |
| RTECS# | XI0250000 |
Transport Information:
| HS Number | 2941900000 |
Application
Cefotaxime Sodium Salt: a Third Generation Cephalosporin Antibiotic
Cefotaxime sodium salt is a third generation semisynthetic cephalosporin antibiotic, which is chemically synthesized form 7-aminocephalosporanic acid (7-ACA) [A1266]. It has a broad spectrum of activity against Gram-positive and Gram-negative aerobic and anaerobic bacteria, and is generally more active against Gram-negative bacteria than the first and second generation cephalosporins. It has increased stability to β-lactamases compared with the first and second generation cephalosporins. Furthermore, it penetrates well into various body compartments. Recently, it has been reported it as a corrosion inhibitor for mild steel in hydrochloric acid solution.
References
- Cefotaxime: a review of in vitro antimicrobial properties and spectrum of activity
- Cefotaxime (an overview)
- Drug utilization review (DUR) of the third generation cephalosporins: Focus on ceftriaxone, ceftazidime and cefotaxime
- Cefotaxime and desacetylcefotaxime antimicrobial interactions. The clinical relevance of enhanced activity: a review
- Cefotaxime sodium: A new and efficient corrosion inhibitor for mild steel in hydrochloric acid solution
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