Maintenance Notice (5:15 AM - 4:55 PM May 24, 2025): This website is scheduled to be unavailable due to maintenance. We appreciate your patience and understanding.
Published TCIMAIL newest issue No.198
Maximum quantity allowed is 999
Please select the quantity
CAS RN: 59865-13-3 | Product Number: C2408
Cyclosporin A
×
![]()
×
Purity: >97.0%(HPLC)(N)
Synonyms:
- Cyclosporin
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 100MG |
€22.00
|
1 | ≥40 |
|
| 1G |
€140.00
|
2 | ≥40 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | C2408 |
| Purity / Analysis Method | >97.0%(HPLC)(N) |
| Molecular Formula / Molecular Weight | C__6__2H__1__1__1N__1__1O__1__2 = 1,202.64 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 100MG-Glass Bottle with Plastic Insert (View image), 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 59865-13-3 |
| Reaxys Registry Number | 3647785 |
| PubChem Substance ID | 125307331 |
| Merck Index (14) | 2752 |
| MDL Number | MFCD00274558 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(with Total Nitrogen) | min. 97.0 % |
| Melting point | 145.0 to 150.0 °C |
| Specific rotation [a]20/D | -185 to -193 deg(C=0.5, MeOH) |
Properties (reference)
| Melting Point | 151 °C |
| Specific Rotation | -193° (C=0.5,MeOH) |
| Solubility (soluble in) | Chloroform |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H302 : Harmful if swallowed. H360 : May damage fertility or the unborn child. H362 : May cause harm to breast-fed children. H350 : May cause cancer. |
| Precautionary Statements | P263 : Avoid contact during pregnancy and while nursing. P260 : Do not breathe dust. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. |
Related Laws:
| RTECS# | GZ4120000 |
Transport Information:
| HS Number | 2941900000 |
Application
Paraptosis research / Paraptosis like cell death
Reference
- Endoplasmic reticulum vacuolation and unfolded protein response leading to paraptosis like cell death in cyclosporine A treated cancer cervix cells is mediated by cyclophilin B inhibition
- 1) Assessing the impact of cyclosporin A on lentiviral transduction and preservation of human hematopoietic stem cells in clinically relevant ex vivo gene therapy settings
- Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
- Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation
- The mechanism of action of cyclosporin A and FK506
- Cyclosporin A, FK-506, and rapamycin: Pharmacologic probes of lymphocyte signal transduction
- Mechanisms of action of cyclosporine
- Complex contribution of cyclophilin D to Ca2+-induced permeability transition in brain mitochondria, with relation to the bioenergetic state
- Inhibition of cyclophilin D by cyclosporin A promotes retinal ganglion cell survival by preventing mitochondrial alteration in ischemic injury
Application
Lentivirus vector transduction enhancer
Cyclosporin A improves lentiviral vector transduction efficiency of human hematopoietic stem and progenitor cells.1) Combination of cyclosporine A with prostaglandin E2 further improves the efficiency.
References
Application
Cyclosporin A: A Calcineurin Inhibitor with Immunosuppressive Properties
Cyclosporin A (CsA) is a cyclic polypeptide immunosuppressant, and was initially isolated from the fungus Tolypocladium inflatum Gams in 1970. Cyclosporin A is practically insoluble in water, soluble in diethyl ether, and very soluble in methanol, ethanol and acetonitrile. Cyclosporin A inhibits T-lymphocyte activation, although the exact mechanism of action is not known. Experimental evidence suggests that cyclosporin A is inactive by itself and requires binding to an intracellular protein, cyclophiline D (CypD), for activation in cells. A complex of CsA–CypD, calcium, calmodulin, and calcineurin (a calcium and calmodulin dependent protein phosphatase) is then formed and the phosphatase activity of calcineurin inhibited. This effect may prevent both T-lymphocyte signal transduction and IL-2 transcription. Tacrolimus (FK506) [M2258] is also inhibits calcineurin and is more potent than cyclosporin A. Cyclosporin A is mainly metabolized by cytochrome P 450 IIIA (CYP3A) subfamilies. (The product is for research purpose only.)
References
PubMed Literature
Documents
Product Articles
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
Please select Language.
The requested SDS is not available.
Please Contact Us for more information.
Specifications
C of A & Other Certificates
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
Sample C of A
This is a sample C of A and may not represent a recently manufactured lot of the product.
A sample C of A for this product is not available at this time.
Analytical Charts
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
The requested analytical chart is not available. Sorry for the inconvenience.