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CAS RN: 461432-26-8 | Product Number: D6234
Dapagliflozin
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Purity: >95.0%(HPLC)
Synonyms:
- (1S)-1,5-Anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucitol
- (1S)-1,5-Anhydro-1-[4-chloro-3-(4-ethoxybenzyl)phenyl]-D-glucitol
- BMS 512148
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 1G |
€98.00
|
Contact Us | 33 |
|
|
| 5G |
€315.00
|
Contact Us | 3 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | D6234 |
Purity / Analysis Method 
|
>95.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__1H__2__5ClO__6 = 408.88 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (<0°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 461432-26-8 |
| Reaxys Registry Number | 11966426 |
| MDL Number | MFCD13182359 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Specific rotation | +15.0 to +19.0 deg(C=0.1, CHCl3) |
| Water | max. 2.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 88 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H361 : Suspected of damaging fertility or the unborn child. H362 : May cause harm to breast-fed children. |
| Precautionary Statements | P263 : Avoid contact during pregnancy and while nursing. P260 : Do not breathe dust or mist. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. |
Related Laws:
Transport Information:
| HS Number | 2932990090 |
Application
Dapagliflozin: A Sodium-Dependent Glucose Transporter 2 (SGLT2) Inhibitor
Sodium-dependent glucose transporter 2 (SGLT2), expressed in the proximal renal tubules, is responsible for most of the reabsorption of filtered glucose from the tubular lumen.1) The inhibitors, including dapagliflozin (BMS-512148), suppress the reabsorption of filtered glucose in the proximal renal tubules.2-4) Therefore, the inhibitors can control blood glucose by excreting excess glucose in the urine. SGLT2 inhibitors also reduce sodium reabsorption and increase sodium delivery to the distal tubule. This has been reported to affect several physiological functions, including the reduction of cardiac preload and afterload.5) (The product is for research purpose only.)
References
- 1) The human kidney low affinity Na+/glucose cotransporter SGLT2. Delineation of the major renal reabsorptive mechanism for D-glucose.
- 2) Dapagliflozin Dapagliflozin, a selective SGLT2 inhibitor, improves glucose homeostasis in normal and diabetic rats
- 3) In vitro characterization and pharmacokinetics of dapagliflozin (BMS-512148), a potent sodium-glucose cotransporter type II inhibitor, in animals and humans
- 4) Clinical Pharmacokinetics and Pharmacodynamics of Dapagliflozin, a Selective Inhibitor of Sodium-Glucose Co-transporter Type 2 (a review)
- 5) SGLT2 inhibitors and mechanisms of cardiovascular benefit: a state-of-the-art review
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