Published TCIMAIL newest issue No.201
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CAS RN: 114-07-8 | Product Number: E0751
Erythromycin
×
Purity: >98.0%(T)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 5G |
€39.00
|
16 | ≥60 |
|
|
| 25G |
€123.00
|
4 | 33 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
Supplemental Product Information:
This product has not been tested for potency and is guaranteed for chemical purity.
| Product Number | E0751 |
Purity / Analysis Method 
|
>98.0%(T) |
| Molecular Formula / Molecular Weight | C__3__7H__6__7NO__1__3 = 733.94 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Hygroscopic |
| CAS RN | 114-07-8 |
| Reaxys Registry Number | 75279 |
| PubChem Substance ID | 87559996 |
| Merck Index (14) | 3681 |
| MDL Number | MFCD00084654 |
Specifications
| Appearance | White to Orange to Green powder to crystal |
| Purity(Nonaqueous Titration) | min. 98.0 %(calcd.on anh.substance) |
| Specific rotation [a]20/D | -71.0 to -78.0 deg(C=2, EtOH)(calcd.on anh.substance) |
| Water | max. 10.0 % |
Properties (reference)
| Specific Rotation | -74° (C=2,EtOH) |
| Solubility (soluble in) | 1,2-Dichloroethane, Ether |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H317 : May cause an allergic skin reaction. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust. P272 : Contaminated work clothing should not be allowed out of the workplace. P280 : Wear protective gloves. P362 + P364 : Take off contaminated clothing and wash it before reuse. P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention. |
Related Laws:
| EC Number | 204-040-1 |
| RTECS# | KF4375000 |
Transport Information:
| HS Number | 2941500000 |
Application
Biofilm research
It has been reported that susceptibility of Actinobacillus actinomycetemcomitans, strain 310a, biofilm to erythromycin decreases as biofilm matures.1) Adding 10 mg/L of the antibiotic reduced biofilm development in the early phase, but it enhanced biofilm development in the mature phase.
(The product is for research purpose only.)
(The product is for research purpose only.)
Reference
- Susceptibility of Actinobacillus actinomycetemcomitans to six antibiotics decreases as biofilm matures
- Erythromycin (a review)
- The macrolides: erythromycin, clarithromycin, and azithromycin (a review)
- Erythromycin resistance by ribosome modification (a review)
- Erythromycin and other macrolides as prokinetic agents (a review)
- Macrolides: from in vitro anti-inflammatory and immunomodulatory properties to clinical practice in respiratory diseases (a review)
Application
Erythromycin: The First Macrolide Antibiotic
Macrolide antibiotics are classified by the size of the macrocyclic lactone ring of aglycone as 14-, 15- or 16-membered ring macrolides. Macrolides are characterized by similar chemical structures, mechanisms of action and resistance, but vary in the different pharmacokinetic parameters, and spectrum of activity. Erythromycin (abbrev: EM), the first 14-membered macrolide, is isolated from a strain of the actinomycete Saccharopolyspora erythraea. EM has activity against a wide range of Gram-positive bacteria including Streptococcus and Staphylococcus, and limited activity against Gram-negative bacteria. EM inhibits protein synthesis in susceptible organisms by binding to specific nucleotides in 23S rRNA within the 50S subunit of the bacterial ribosome. EM and macrolides also shows gastrointestinal motor stimulating activity as a motilin-agonist, and anti-inflammatory or immunomodulatory activity. EM is easily inactivated by gastric acid. Therefore, a number of more stable macrolides such as azithromycin [A2076] and clarithromycin [C2220] have been chemically synthesized from EM.
References
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