Published TCIMAIL newest issue No.199
Maximum quantity allowed is 999
Please select the quantity
CAS RN: 152044-54-7 | Product Number: E1378
Epothilone B
×
![]()
×
Purity: >95.0%(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 5MG |
€ 100,00
|
1 | 5 |
|
|
| 25MG |
€ 385,00
|
Contact Us | 26 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | E1378 |
Purity / Analysis Method 
|
>95.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__7H__4__1NO__6S = 507.69 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (-20°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 152044-54-7 |
| Reaxys Registry Number | 7556514 |
| PubChem Substance ID | 468591745 |
| Merck Index (14) | 3628 |
| MDL Number | MFCD02101921 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Specific rotation [a]20/D | -40.0 to -44.0 deg (C=0.2, methanol) |
| Elemental analysis(Carbon) | 62.50 to 65.00 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 94 °C |
| Specific Rotation | -36° (C=0.2,MeOH) |
| Maximum Absorption Wavelength | 249 nm (MeOH) |
GHS
Related Laws:
| RTECS# | JG6799500 |
Transport Information:
Application
Epothilone B: A Microtubule Inhibitor
Epothilone B, a natural macrolide compound, is a microtubule inhibitor belonging to a class of antineoplastic agents. Epothilone B was originally isolated from the cellulose-degrading myxobacteria Sorangium cellulosum. Epothilone B has a mode of action analogous to that of paclitaxel [P1632]. It binds directly to β-tubulin subunits on microtubules, stabilizing microtubules. It blocks cells in the mitotic phase of the cell division cycle, leading to cell death. Epothilone B has poor metabolic stability and unfavorable pharmacokinetics.1-4) Therefore, its analogs (e.g. Ixabepilone; BMS-247550) were synthesized and used in clinical.4) (The product is for research purpose only.)
文献
- 1) Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action
- 2) Epothilons A and B: antifungal and cytotoxic compounds from Sorangium cellulosum (Myxobacteria). Production, physico-chemical and biological properties.
- 3) Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxol)
- 4) Epothilones: Mechanism of action and biologic activity (a review)
- 5) In vivo metabolism of epothilone B in tumor-bearing nude mice: identification of three new epothilone B metabolites by capillary high-pressure liquid chromatography/mass spectrometry/tandem mass spectrometry
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
Please select Language.
The requested SDS is not available.
Please Contact Us for more information.
Specifications
C of A & Other Certificates
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
Sample C of A
This is a sample C of A and may not represent a recently manufactured lot of the product.
A sample C of A for this product is not available at this time.
Analytical Charts
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
The requested analytical chart is not available. Sorry for the inconvenience.