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Published TCIMAIL newest issue No.198
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CAS RN: 13311-84-7 | Product Number: F0663
Flutamide
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Purity: >98.0%(GC)
Synonyms:
- 4'-Nitro-3'-(trifluoromethyl)isobutyranilide
- 2-Methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propionamide
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 5G |
€30.00
|
1 | 32 |
|
| 25G |
€96.00
|
1 | 15 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | F0663 |
Purity / Analysis Method 
|
>98.0%(GC) |
| Molecular Formula / Molecular Weight | C__1__1H__1__1F__3N__2O__3 = 276.22 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Condition to Avoid | Light Sensitive |
| CAS RN | 13311-84-7 |
| Reaxys Registry Number | 2157663 |
| PubChem Substance ID | 87560202 |
| Merck Index (14) | 4208 |
| MDL Number | MFCD00072009 |
Specifications
| Appearance | White to Light yellow to Green powder to crystal |
| Purity(GC) | min. 98.0 % |
| Melting point | 110.0 to 114.0 °C |
Properties (reference)
| Melting Point | 112 °C |
| Solubility in water | Insoluble |
| Solubility (soluble in) | Chloroform, Ether |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. H361 : Suspected of damaging fertility or the unborn child. H370 : Causes damage to organs. |
| Precautionary Statements | P260 : Do not breathe dust. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor. |
Related Laws:
| EC Number | 236-341-9 |
| RTECS# | UG5700000 |
Transport Information:
| HS Number | 2924297099 |
Application
Flutamide: A Non-Steroidal Androgen Receptor Antagonist
Flutamide (SCH 13521) and bicalutamide [B3206] are non-steroidal androgen receptor antagonists with antiandrogenic activity. Testosterone [T0027], the most important androgen, converted to 5α-dihydrotestosterone (DHT) [A0462] by 5α-reductase type 2 which reduces the 4,5-double bond of testosterone in prostate cells. DHT has two or three times greater androgen receptor (AR) affinity than testosterone. Upon DHT binding, the AR undergoes a conformational change and releases heat shock proteins (HSPs), resulting in mRNA expression and prostate cell proliferation. Flutamide is rapidly metabolized by hydroxylation of the side chain to primary active form 2-hydroxyflutamide [H1600]. Subsequently, 2-hydroxyflutamide acts as a potent and highly selective competitive antagonist of the AR, blocks the conversion of testosterone to DHT, and inhibits the proliferation of prostate cells. Flutamide and bicalutamide are used for the treatment of prostate cancer and other androgen-dependent conditions. (The product is for research purpose only.)
References
- Biological profile of a nonsteroidal antiandrogen, SCH 13521 (4'-nitro-3'-trifluoromethylisobutyranilide)
- Characteristics of interaction of the antiandrogen flutamide with the androgen receptor in various target tissues
- Mechanism of action and pure antiandrogenic properties of flutamide
- Selection for androgen receptor mutations in prostate cancers treated with androgen antagonist
- Flutamide. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in advanced prostatic cancer
- Flutamide. A review of methods of preparation, physical properties, stability, metabolism and pharmacokinetics and methods for the detection of flutamide
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