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Published TCIMAIL newest issue No.198
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CAS RN: 436-77-1 | Product Number: F1173
Fangchinoline
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Purity: >97.0%(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 20MG |
124,00 €
|
1 | 31 |
|
| 100MG |
397,00 €
|
Contact Us | 25 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | F1173 |
Purity / Analysis Method 
|
>97.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__3__7H__4__0N__2O__6 = 608.74 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 436-77-1 |
| Reaxys Registry Number | 78975 |
| PubChem Substance ID | 468591833 |
| MDL Number | MFCD00221726 |
Specifications
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Elemental analysis(Nitrogen) | 4.00 to 5.00 % |
Properties (reference)
| Melting Point | 238 °C(dec.) |
| Maximum Absorption Wavelength | 283 nm (EtOH) |
GHS
Related Laws:
| RTECS# | DR9280000 |
Transport Information:
| HS Number | 2939799090 |
Application
Fangchinoline: An Alkaloid with Diverse Pharmacological Effects Including Significant Antitumor Activities
Fangchinoline and tetrandrine [T3321] are the major alkaloids from Stephenia tetrandra S Moore which is a plant indigenous to main land of China that has long been used as a Chinese herb. Stephenia tetrandra S Moore is traditionally used as analgesic, antirheumatic, and antihypertensive drug.1,2) Recently, fangchinoline has been found to exhibit diverse pharmacological effects including significant antitumor activities.3-5) (The product is for research purpose only.)
References
- 1) Vasodilating and hypotensive effects of fangchinoline and tetrandrine on the rat aorta and the stroke-prone spontaneously hypertensive rat
- 2) Anti-inflammatory effects of fangchinoline and tetrandrine
- 3) Fangchinoline induced G1/S arrest by modulating expression of p27, PCNA, and cyclin D in human prostate carcinoma cancer PC3 cells and tumor xenograft
- 4) Fangchinoline induces autophagic cell death via p53/sestrin2/AMPK signalling in human hepatocellular carcinoma cells
- 5) Molecular targets modulated by fangchinoline in tumor cells and preclinical models (a review)
- 6) Detection of aristolochic acid I, tetrandrine and fangchinoline in medicinal plants by high performance liquid chromatography and liquid chromatography/mass spectrometry
- 7) Determination of tetrandrine and fangchinoline in plasma samples using hollow fiber liquid-phase microextraction combined with high-performance liquid chromatography
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