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Published TCIMAIL newest issue No.198
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CAS RN: 1217503-60-0 | Product Number: H1525
(1E,4E)-1-(4-Hydroxy-3,5-dimethoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-1,4-pentadiene-3-one
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Purity: >95.0%(HPLC)
Synonyms:
- GO-Y078
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 20MG |
€69.00
|
Contact Us | 11 |
|
| 100MG |
€219.00
|
Contact Us | 11 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | H1525 |
| Purity / Analysis Method | >95.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__2H__2__4O__7 = 400.43 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 1217503-60-0 |
| Reaxys Registry Number | 20091460 |
| PubChem Substance ID | 354333647 |
Specifications
| Appearance | White to Yellow to Orange powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
Properties (reference)
GHS
Related Laws:
| EC Number | 274-722-1 |
Transport Information:
| HS Number | 2914500090 |
Application
GO-Y078: A New Curcumin Analogue with Enhanced Antitumor Activities
Curcumin [C0434][C2302] has chemopreventive and chemotherapeutic potentials against various types of cancers, but low bioavailability prevents its use in chemotherapeutic applications. GO-Y078 and GO-Y030 [B4823] are new synthetic analogues of curcumin, developed by Shibata, Iwabuchi et al. to increase its potential and circumvent its low bioavailability.1,2) In their reports, GO-Y078 and GO-Y030 suppress the growth of myeloma cells, and are 7 to 12 times more effective than curcumin. GO-Y078 and GO-Y030 are also 6- to 15-fold stronger multi-target inhibitors (eg. nuclear factor-κB (NFκB)) than curcumin. Furthermore, GO-Y078 inhibits tumor angiogenesis through actin disorganization.3) In addition, the water solubility of GO-Y078 (1.07 mg/L) is 2 times higher than that of curcumin (0.54 mg/L).4) (The product is for research purpose only.)
References
- 1)Structure-activity relationship of C5-curcuminoids and synthesis of their molecular probes thereof
- 2)Novel curcumin analogs, GO-Y030 and GO-Y078, are multi-targeted agents with enhanced abilities for multiple myeloma
- 3)A curcumin analog, GO-Y078, effectively inhibits angiogenesis through actin disorganization
- 4)Synthesis of 86 species of 1,5-diaryl-3-oxo-1,4-pentadienes analogs of curcumin can yield a good lead in vivo
PubMed Literature
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